Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis. (Q52573774)

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scientific article published on 17 April 2018

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English	Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis.	scientific article published on 17 April 2018

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24 March 2020

Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis (English)

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24 March 2020

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Xihui Zhang

1

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24 March 2020

Liecheng Yang

2

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24 March 2020

Yongming Liu

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24 March 2020

Zhentao Song

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24 March 2020

Jian Zhao

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24 March 2020

Dandan Chen

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24 March 2020

Huan Yu

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24 March 2020

Ruibin Li

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24 March 2020

Yangyun Wang

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24 March 2020

Kai Yang

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24 March 2020

Yu Chen

11

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24 March 2020

Menghang Xia

12

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24 March 2020

Leshuai W Zhang

13

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24 March 2020

publication date

18 April 2018

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24 March 2020

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13

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Toxicology and Applied Pharmacology

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24 March 2020

348

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24 March 2020

54-66

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24 March 2020

Aminoglycoside-induced renal phospholipidosis and nephrotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Time-dependent effects of chloroquine on pH of hepatocyte lysosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities

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https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Amiodarone-induced phospholipidosis in rat alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Amiodarone-induced hepatic phospholipidosis: Correlation of morphological and biochemical findings in an animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Amiodarone-induced hepatic phospholipidosis: A morphological alteration independent of pseudoalcoholic liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Increased hepatic density and phospholipidosis due to amiodarone

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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In vivo and in vitro reversibility of chlorphentermine-induced phospholipidosis in rat alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Ketoconazole-induced hepatic phospholipidosis in the mouse and its association with de-N-acetyl ketoconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Cationic amphiphilic drug-induced phospholipidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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The differential cytotoxicity of methotrexate in rat hepatocyte monolayer and spheroid cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Drug-induced phospholipidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Nanotechnology: a focus on nanoparticles as a drug delivery system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Nanotechnology-based drug delivery systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Improved isolation of murine hepatocytes for in vitro malaria liver stage studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Superior thermal conductivity of single-layer graphene

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Phospholipidosis in healthy subjects participating in clinical studies: ultrastructural findings in white blood cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Relationship between in vitro phospholipidosis assay using HepG2 cells and 2-week toxicity studies in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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A strategy for risk management of drug-induced phospholipidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Comparative analysis of gene expression in rat liver tissue and monolayer- and spheroid-cultured hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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Nano-Graphene Oxide for Cellular Imaging and Drug Delivery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Expression of organ-specific structures and functions in long-term cultures of aggregates from adult rat liver cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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Biomedical applications of graphene

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Drug induced phospholipidosis: an acquired lysosomal storage disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Safety considerations for graphene: lessons learnt from carbon nanotubes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in liver and kidney in ketoconazole-treated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Injectable nanomaterials for drug delivery: carriers, targeting moieties, and therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Surface plasmon enhanced drug efficacy using core-shell Au@SiO2 nanoparticle carrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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Preparation and functionalization of graphene nanocomposites for biomedical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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Drug delivery/imaging multifunctionality of mesoporous silica-based composite nanostructures

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

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Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model

1 reference

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12 December 2020

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Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish.

1 reference

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12 December 2020

based on heuristic

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Toxicity assessment of hydroxyapatite nanoparticles in rat liver cell model in vitro

1 reference

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12 December 2020

based on heuristic

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Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29678448

12 December 2020

based on heuristic

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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

1 reference

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12 December 2020

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From the Cover: Potentiation of Drug-Induced Phospholipidosis In Vitro through PEGlyated Graphene Oxide as the Nanocarrier.

1 reference

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12 December 2020

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Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material.

1 reference

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12 December 2020

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The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice

1 reference

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12 December 2020

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Network Analysis of Drug-target Interactions: A Study on FDA-approved New Molecular Entities Between 2000 to 2015

1 reference

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12 December 2020

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10.1016/J.TAAP.2018.04.016

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24 March 2020

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24 March 2020

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