A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea. (Q52564507)

3 May 2018

title

A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea. (English)

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8

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author name string

Steven Boakes

1

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Markiyan Oliynyk

2

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Jesús Cortés

3

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Ines Böhm

4

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Brian A M Rudd

5

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W Peter Revill

6

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Jim Staunton

7

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publication date

1 January 2004

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3 May 2018

Journal of Molecular Microbiology and Biotechnology

published in

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volume

8

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issue

2

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page(s)

73-80

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

cites work

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Big effects from small changes: possible ways to explore nature's chemical diversity.

21 January 2018

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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

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High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes.

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Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea

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Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

21 January 2018

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A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases

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Diversifying microbial natural products for drug discovery

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Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

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Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

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A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

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Drugs from the seas - current status and microbiological implications

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Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).

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Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

21 January 2018

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Myxobacteria, producers of novel bioactive substances

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A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

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Construction of new vectors for high-level expression in actinomycetes.

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Combinatorial biosynthesis of antibiotics: challenges and opportunities

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How many antibiotics are produced by the genus Streptomyces?

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A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

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Cultivating the uncultured

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Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000084562

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3 May 2018

PubMed ID

15925898

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3 May 2018