Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosa. (Q51810835)

12 April 2018

title

Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosa. (English)

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12 April 2018

author name string

Hideaki Shirasaki

1

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12 April 2018

Megumi Kikuchi

2

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12 April 2018

Etsuko Kanaizumi

3

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12 April 2018

Tetsuo Himi

4

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12 April 2018

publication date

1 February 2009

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12 April 2018

Annals of Allergy, Asthma & Immunology

published in

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12 April 2018

volume

102

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12 April 2018

issue

2

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12 April 2018

page(s)

110-115

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12 April 2018

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

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Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

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Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa

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CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

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Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

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Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

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Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells

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Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway.

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An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro

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Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

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Identifiers

DOI

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12 April 2018

PubMed ID

19230460

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12 April 2018