A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. (Q51747259)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29483571%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders (English)

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18 March 2020

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13

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18 March 2020

Manish Thakur

21

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18 March 2020

author name string

Aimo Kannt

1

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18 March 2020

Sridharan Rajagopal

2

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18 March 2020

Sanjay Venkatachalapathi Kadnur

3

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18 March 2020

Juluri Suresh

4

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18 March 2020

Ravi Kanth Bhamidipati

5

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18 March 2020

Srinivasan Swaminathan

6

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18 March 2020

Mahanandeesha Siddappa Hallur

7

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18 March 2020

Rajendra Kristam

8

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18 March 2020

Ralf Elvert

9

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18 March 2020

Jörg Czech

10

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18 March 2020

Anja Pfenninger

11

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18 March 2020

Christine Rudolph

12

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18 March 2020

Devaraj Venkatapura Chandrasekar

14

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18 March 2020

Vishal Subhash Mane

15

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18 March 2020

Swarnakumari Birudukota

16

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18 March 2020

Shama Shaik

17

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18 March 2020

Bharat Ravindra Zope

18

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18 March 2020

Raghunadha Reddy Burri

19

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18 March 2020

Niranjan Naranapura Anand

20

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18 March 2020

Manvi Singh

22

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18 March 2020

Reejuana Parveen

23

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18 March 2020

Saravanan Kandan

24

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18 March 2020

Ramesh Mullangi

25

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18 March 2020

Takeshi Yura

26

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18 March 2020

Ramachandraiah Gosu

27

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18 March 2020

Sven Ruf

28

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18 March 2020

Saravanakumar Dhakshinamoorthy

29

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18 March 2020

language of work or name

English

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publication date

26 February 2018

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18 March 2020

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18 March 2020

volume

8

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18 March 2020

issue

1

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18 March 2020

page(s)

3660

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Creative Commons Attribution 4.0 International

18 March 2020

copyright license

start time

26 February 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide

1 reference

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Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase.

22 May 2018

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Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme

22 May 2018

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A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase.

22 May 2018

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Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.

22 May 2018

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Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese

22 May 2018

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Potential involvement of nicotinamide N-methyltransferase in the pathogenesis of metabolic syndrome

22 May 2018

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Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance

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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

22 May 2018

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NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

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Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides

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Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer

22 May 2018

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22 May 2018

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22 May 2018

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The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice

22 May 2018

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22 May 2018

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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

13 August 2018

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13 August 2018

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Interferon-gamma elevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells

13 August 2018

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13 August 2018

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13 August 2018

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Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.

30 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-018-22081-7

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7 January 2021

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PROCHECK: a program to check the stereochemical quality of protein structures

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7 January 2021

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10.1038/S41598-018-22081-7

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18 March 2020

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18 March 2020

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