Expression of 4-1BB and its ligand on blasts correlates with prognosis of patients with AML. (Q51656832)

9 April 2018

title

Expression of 4-1BB and its ligand on blasts correlates with prognosis of patients with AML. (English)

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9 April 2018

author name string

Joerg U Schmohl

1

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9 April 2018

Tina Nuebling

2

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Julia Wild

3

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Tanja Kroell

4

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Lothar Kanz

5

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Helmut R Salih

6

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Helga Schmetzer

7

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publication date

7 July 2016

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Journal of Investigative Medicine

published in

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volume

64

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issue

8

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page(s)

1252-1260

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Expression of RANK-L and in part of PD-1 on blasts in patients with acute myeloid leukemia correlates with prognosis

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4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12.

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4-1BB as a therapeutic target for human disease

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In vivo 4-1BB deficiency in myeloid cells enhances peripheral T cell proliferation by increasing IL-15.

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Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma.

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CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.

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Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies.

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The erythroid leukemias: a comparative study of erythroleukemia (FAB M6) and Di Guglielmo disease

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Characterization and application of three novel monoclonal antibodies against human 4-1BB: distinct epitopes of human 4-1BB on lung tumor cells and immune cells

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Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity.

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Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma

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Recombinant glucocorticoid induced tumour necrosis factor receptor (rGITR) induced COX-2 activity in murine macrophage Raw 264.7 cells.

21 January 2018

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CD28/B7 system of T cell costimulation

21 January 2018

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The B7-CD28 superfamily

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The expression of co-stimulatory molecules and their relationship to the prognosis of human acute myeloid leukaemia: poor prognosis of B7-2-positive leukaemia.

21 January 2018

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Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules

21 January 2018

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High expression of costimulatory molecules correlates with low relapse-free survival probability in acute myeloid leukemia (AML).

21 January 2018

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Expression of the co-stimulatory molecule B7 on melanoma cells

21 January 2018

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Expression of costimulatory molecules, B7-1 and B7-2 on human gastric carcinoma

21 January 2018

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Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia

21 January 2018

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21 January 2018

Identifiers

DOI

10.1136/JIM-2016-000081

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9 April 2018

PubMed ID

27388616

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9 April 2018