Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. (Q51573853)

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20 March 2020

title

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation (English)

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20 March 2020

6

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20 March 2020

Sheng Chih Jin

4

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20 March 2020

Marina Cella

5

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20 March 2020

9

Marco Colonna

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20 March 2020

8

Rudolph E Tanzi

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20 March 2020

3

Kristina Mullin

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20 March 2020

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Wilbur Song

1

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20 March 2020

Basavaraj Hooli

2

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20 March 2020

Yaming Wang

7

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20 March 2020

publication date

9 August 2016

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20 March 2020

published in

Alzheimer's and Dementia

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20 March 2020

volume

13

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20 March 2020

issue

4

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20 March 2020

page(s)

381-387

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CD33 modulates TREM2: convergence of Alzheimer loci.

20 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

TREM2 sustains microglial expansion during aging and response to demyelination

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

TREM2 is associated with increased risk for Alzheimer's disease in African Americans

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Innate immunity in Alzheimer's disease

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Coding variants in TREM2 increase risk for Alzheimer's disease

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

TREM2 Variants in Alzheimer's Disease

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Impaired differentiation of osteoclasts in TREM-2-deficient individuals

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5299056

10.1016/J.JALZ.2016.07.004

14 August 2018

Identifiers

DOI

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20 March 2020

1 reference

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20 March 2020

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