Formic acid excretion in rats exposed to trichloroethylene: a possible explanation for renal toxicity in long-term studies. (Q51505954)

6 April 2018

title

Formic acid excretion in rats exposed to trichloroethylene: a possible explanation for renal toxicity in long-term studies. (English)

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6 April 2018

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T Green

1

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6 April 2018

J Dow

series ordinal

2

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6 April 2018

J R Foster

series ordinal

3

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6 April 2018

P M Hext

series ordinal

4

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6 April 2018

language of work or name

English

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publication date

1 May 1998

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6 April 2018

published in

Toxicology

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6 April 2018

volume

127

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6 April 2018

issue

1-3

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6 April 2018

page(s)

39-47

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6 April 2018

Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure

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Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.

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Identification of N-acetyl(2,2-dichlorovinyl)- and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat.

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Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

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Metabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation.

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Inhibitors of cytochrome c oxidase

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Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.

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Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.

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Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.

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Potential role of alpha-2 mu-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane

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Improved enzymic assay for serum formate with colorimetric endpoint

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Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes

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The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.

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Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species.

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Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene

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Chloride/formate exchange with formic acid recycling: a mechanism of active chloride transport across epithelial membranes

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Effect of renal formic acid excretion on urinary calcium and ammonia concentrations

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Methanol and Formic Acid Toxicity: Biochemical Mechanisms

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Acute and chronic toxicity of formic acid and its formates

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Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice.

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The effect of formate on cytochrome aa3 and on electron transport in the intact respiratory chain

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7 January 2021

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A PATHOLOGICAL STUDY ON THE TOXICITY OF S-DICHLOROVINYL-L-CYSTEINE

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Identifiers

DOI

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6 April 2018

1 reference

6 April 2018