Collagen type IV alpha 3 chain (Q5145905)

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mammalian protein found in Homo sapiens

• tumstatin
• COL4A3
• collagen IV, alpha-3 polypeptide
• collagen alpha-3(IV) chain
• collagen, type IV, alpha 3 (Goodpasture antigen)
• Goodpasture antigen

edit

Language	Label	Description	Also known as
English	Collagen type IV alpha 3 chain	mammalian protein found in Homo sapiens	tumstatin COL4A3 collagen IV, alpha-3 polypeptide collagen alpha-3(IV) chain collagen, type IV, alpha 3 (Goodpasture antigen) Goodpasture antigen

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q01955

part of

Collagen IV, non-collagenous domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q01955

C-type lectin fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q01955

Collagen IV, non-collagenous, protein family

1 reference

based on heuristic

inferred from protein domain or family

collagen triple helix repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q01955

encoded by

COL4A3

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q01955

molecular function

extracellular matrix structural constituent

determination method

IEA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01955&geneProductId=UniProtKB:Q01955

determination method

IEA

structural molecule activity

determination method

NAS

1 reference

retrieved

8 April 2019

stated in

Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

NAS

protein binding

determination method

IPI

2 references

retrieved

8 April 2019

stated in

Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IPI

retrieved

8 April 2019

stated in

Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IPI

metalloendopeptidase inhibitor activity

determination method

NAS

1 reference

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

NAS

integrin binding

determination method

TAS

IDA

2 references

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

TAS

retrieved

8 April 2019

stated in

Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

extracellular matrix structural constituent

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IBA

extracellular matrix structural constituent conferring tensile strength

determination method

HDA

2 references

retrieved

1 January 2018

stated in

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01955&geneProductId=UniProtKB:Q01955

determination method

HDA

retrieved

1 January 2018

stated in

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01955&geneProductId=UniProtKB:Q01955

determination method

HDA

extracellular matrix structural constituent conferring tensile strength

determination method

IEA

RCA

6 references

retrieved

1 January 2018

stated in

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

RCA

retrieved

1 January 2018

stated in

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

RCA

retrieved

1 January 2018

stated in

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

RCA

retrieved

1 January 2018

stated in

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

1 January 2018

stated in

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

1 January 2018

stated in

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

extracellular matrix structural constituent conferring tensile strength

determination method

HDA

RCA

3 references

retrieved

8 April 2019

stated in

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

RCA

retrieved

8 April 2019

stated in

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

RCA

retrieved

8 April 2019

stated in

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

HDA

cell component

collagen

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

endoplasmic reticulum lumen

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

TAS

intracellular membrane-bounded organelle

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

endoplasmic reticulum

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

extracellular region

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

basement membrane

determination method

IEA

IDA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

collagen type IV trimer

determination method

IEA

IDA

2 references

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01955&geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

24 April 2018

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01955&geneProductId=UniProtKB:Q01955

determination method

IDA

collagen type IV trimer

determination method

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IBA

extracellular space

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IBA

extracellular matrix

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IBA

collagen-containing extracellular matrix

determination method

HDA

3 references

retrieved

8 April 2019

stated in

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

HDA

retrieved

8 April 2019

stated in

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

HDA

retrieved

8 April 2019

stated in

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

HDA

biological process

extracellular matrix organization

determination method

TAS

1 reference

retrieved

24 April 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01955&geneProductId=UniProtKB:Q01955

determination method

TAS

sensory perception of sound

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Identification of mutations in the alpha 3(IV) and alpha 4(IV) collagen genes in autosomal recessive Alport syndrome

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

TAS

blood circulation

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

TAS

cell adhesion

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

endothelial cell apoptotic process

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

cell population proliferation

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

negative regulation of cell population proliferation

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

TAS

cell surface receptor signaling pathway

determination method

IEA

NAS

2 references

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

negative regulation of endopeptidase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

negative regulation of angiogenesis

determination method

IEA

IDA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

retrieved

8 April 2019

stated in

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

retrieved

8 April 2019

stated in

Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IDA

glomerular basement membrane development

determination method

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q01955

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

collagen-activated tyrosine kinase receptor signaling pathway

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

response to glucose

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IEA

extracellular matrix organization

determination method

IBA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

TAS

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01955

determination method

IBA

physically interacts with

ocriplasmin

object has role

hydrolase

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL2095222

Gene Atlas image

PBB GE COL4A3 214641 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q01955

1 reference

stated in

Identifiers.org

has part(s)

Collagen IV, non-collagenous

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q01955

Collagen triple helix repeat

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q01955

Identifiers

RefSeq protein ID

NP_000082

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1285

XP_005246334

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1285

XP_005246337

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1285

XP_006712308

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1285

XP_011508857

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1285

XP_011508858

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1285

XP_016858784

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1285

UniProt protein ID

Q01955

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q01955

Ensembl protein ID

ENSP00000379823

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379823

ENSP00000302781

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000302781

ENSP00000495177

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000495177

ENSP00000493493

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000493493

Freebase ID

/m/02kg5_v

0 references

 

Sitelinks

Wikipedia(4 entries)

edit

• bswiki COL4A3
• dewiki Kollagen-Typ 4α3
• enwiki Collagen, type IV, alpha 3
• ukwiki COL4A3

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

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Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q5145905&oldid=2022907238"