Collagen type V alpha 1 chain (Q5145890)

Laminin G domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fibrillar collagen, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

collagen triple helix repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 reference

8 April 2019

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

platelet-derived growth factor binding

NAS

1 reference

8 April 2019

Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 reference

8 April 2019

The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

extracellular matrix structural constituent

IPI

1 reference

8 April 2019

Identification of binding partners interacting with the α1-N-propeptide of type V collagen

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Primary structure of the heparin-binding site of type V collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

extracellular matrix structural constituent conferring tensile strength

IBA

5 references

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

extracellular matrix structural constituent conferring tensile strength

HDA

12 references

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

extracellular matrix structural constituent conferring tensile strength

6 references

8 April 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

endoplasmic reticulum lumen

HDA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

TAS

collagen type V trimer

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

extracellular exosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

4 references

17 October 2017

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

3 references

collagen type V trimer

3 references

8 April 2019

Mutations in the COL5A1 gene are causal in the Ehlers-Danlos syndromes I and II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

A point mutation in an intronic branch site results in aberrant splicing of COL5A1 and in Ehlers-Danlos syndrome type II in two British families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

collagen-containing extracellular matrix

IBA

7 references

8 April 2019

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 reference

8 April 2019

Structural abnormalities of the cornea and lid resulting from collagen V mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

negative regulation of endodermal cell differentiation

1 reference

8 April 2019

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

wound healing, spreading of epidermal cells

1 reference

8 April 2019

Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

integrin biosynthetic process

1 reference

8 April 2019

Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

regulation of cellular component organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

extracellular matrix organization

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

1 reference

17 October 2017

Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

blood vessel development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

collagen biosynthetic process

collagen catabolic process

2 references

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

1 reference

8 April 2019

Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

collagen fibril organization

5 references

17 October 2017

The COL5A1 gene and Achilles tendon pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

A point mutation in an intronic branch site results in aberrant splicing of COL5A1 and in Ehlers-Danlos syndrome type II in two British families

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

COL5A1 exon 14 splice acceptor mutation causes a functional null allele, haploinsufficiency of alpha 1(V) and abnormal heterotypic interstitial fibrils in Ehlers-Danlos syndrome II

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908

supramolecular fiber organization

1 reference

8 April 2019

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

collagen fibril organization

6 references

8 April 2019

The COL5A1 gene and Achilles tendon pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

COL5A1 exon 14 splice acceptor mutation causes a functional null allele, haploinsufficiency of alpha 1(V) and abnormal heterotypic interstitial fibrils in Ehlers-Danlos syndrome II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

A point mutation in an intronic branch site results in aberrant splicing of COL5A1 and in Ehlers-Danlos syndrome type II in two British families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908

physically interacts with

IBA

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2095222

Gene Atlas image

PBB GE COL5A1 203325 s at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P20908

1 reference

Fibrillar collagen, C-terminal

Identifiers.org

has part(s)

1 reference

Laminin G domain

1 reference

Collagen triple helix repeat

1 reference

http://www.uniprot.org/uniprot/P20908.txt?172

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

2 references

12 October 2015

14 November 2015

http://www.uniprot.org/uniprot/P20908.txt?version=174

1A9A

2 references

retrieved

12 October 2015