Collagen type II alpha 1 chain (Q5145888)

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mammalian protein found in Homo sapiens

collagen, type II, alpha 1
chondrocalcin
alpha-1 type II collagen
cartilage collagen
collagen alpha-1(II) chain
collagen II, alpha-1 polypeptide
arthroophthalmopathy, progressive (Stickler syndrome)
COL2A1

Language	Label	Description	Also known as
English	Collagen type II alpha 1 chain	mammalian protein found in Homo sapiens	collagen, type II, alpha 1 chondrocalcin alpha-1 type II collagen cartilage collagen collagen alpha-1(II) chain collagen II, alpha-1 polypeptide arthroophthalmopathy, progressive (Stickler syndrome) COL2A1

Statements

1 reference

13 November 2019

UniProt protein ID

VWFC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fibrillar collagen, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

collagen triple helix repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

platelet-derived growth factor binding

determination method

1 reference

8 April 2019

Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular matrix structural constituent conferring tensile strength

determination method

1 reference

17 October 2017

Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

extracellular matrix structural constituent

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

MHC class II protein binding

determination method

1 reference

8 April 2019

X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular matrix structural constituent conferring tensile strength

determination method

5 references

1 January 2018

Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

proteoglycan binding

determination method

1 reference

8 April 2019

Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular matrix structural constituent conferring tensile strength

determination method

9 references

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

1 January 2018

Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular matrix structural constituent conferring tensile strength

determination method

5 references

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

endoplasmic reticulum lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular matrix

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

basement membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular space

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

extracellular region

determination method

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

extracellular region

determination method

3 references

determination method

3 references

collagen type II trimer

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular space

determination method

3 references

8 April 2019

Nonmuscle myosin-dependent synthesis of type I collagen

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

collagen-containing extracellular matrix

determination method

5 references

8 April 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

biological process

proteoglycan metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

central nervous system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

endochondral ossification

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

chondrocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

limb morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

otic vesicle development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

notochord development

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

heart morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

inner ear morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

inner ear development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

tissue homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

regulation of immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

cartilage development involved in endochondral bone morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

determination method

1 reference

8 April 2019

High efficiency of mutation detection in type 1 stickler syndrome using a two-stage approach: vitreoretinal assessment coupled with exon sequencing for screening COL2A1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

skeletal system development

determination method

1 reference

17 October 2017

An amino acid substitution (Gly853-->Glu) in the collagen alpha 1(II) chain produces hypochondrogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

collagen catabolic process

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

bone development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

extracellular matrix organization

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02458&geneProductId=UniProtKB:P02458

determination method

skeletal system morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

cellular response to BMP stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

visual perception

determination method

2 references

roof of mouth development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

embryonic skeletal joint morphogenesis

determination method

1 reference

8 April 2019

High efficiency of mutation detection in type 1 stickler syndrome using a two-stage approach: vitreoretinal assessment coupled with exon sequencing for screening COL2A1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

limb bud formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

cartilage condensation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

collagen fibril organization

determination method

3 references

8 April 2019

An amino acid substitution (Gly853-->Glu) in the collagen alpha 1(II) chain produces hypochondrogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

anterior head development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02458

determination method

http://purl.uniprot.org/uniprot/P02458

1 reference

Identifiers.org

Fibrillar collagen, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02458

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02458

Collagen triple helix repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02458

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000338213

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000338213

ENSP00000369889

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369889

Google Knowledge Graph ID

0 references

Microsoft Academic ID

0 references

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(5 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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