Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model. (Q51453480)

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scientific article published on 28 September 2016

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English	Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model.	scientific article published on 28 September 2016

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scholarly article

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24 March 2020

Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model (English)

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24 March 2020

Kingston H Mills

6

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24 March 2020

Mieszko M. Wilk

2

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24 March 2020

Mathilde Raverdeau

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Mathilde Raverdeau

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author name string

Lydia Dyck

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24 March 2020

Louis Boon

5

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publication date

28 September 2016

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24 March 2020

Cancer Immunology, Immunotherapy

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65

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12

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1491-1498

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24 March 2020

https://scigraph.springernature.com/pub.10.1007/s00262-016-1906-6

0 references

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells.

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Gene silencing of TGF-β1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells

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Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells

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21 January 2018

The blockade of immune checkpoints in cancer immunotherapy

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21 January 2018

Molecular and cellular insights into T cell exhaustion

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21 January 2018

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

1 reference

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21 January 2018

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

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A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

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Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.

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Targeting T Cell Co-receptors for Cancer Therapy

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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

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Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

1 reference

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21 January 2018

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

1 reference

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21 January 2018

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells

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21 January 2018

Identifiers

10.1007/S00262-016-1906-6

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680570%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27680570%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

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