Covalent Guanosine Mimetic Inhibitors of G12C KRAS. (Q51180158)

31 March 2018

title

Covalent Guanosine Mimetic Inhibitors of G12C KRAS. (English)

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31 March 2018

author

Lianbo Li

4

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31 March 2018

Nathanael Gray

12

object named as

Nathanael S Gray

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31 March 2018

author name string

Yuan Xiong

1

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31 March 2018

Jia Lu

2

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31 March 2018

John Hunter

3

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31 March 2018

David Scott

5

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31 March 2018

Hwan Geun Choi

6

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31 March 2018

Sang Min Lim

7

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31 March 2018

Anuj Manandhar

8

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31 March 2018

Sudershan Gondi

9

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31 March 2018

Taebo Sim

10

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31 March 2018

Kenneth D Westover

11

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31 March 2018

publication date

30 November 2016

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31 March 2018

ACS Medicinal Chemistry Letters

published in

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31 March 2018

volume

8

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31 March 2018

issue

1

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31 March 2018

page(s)

61-66

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31 March 2018

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

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22 May 2018

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In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

22 May 2018

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KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Dragging ras back in the ring

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

22 May 2018

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Proteome-wide discovery and characterizations of nucleotide-binding proteins with affinity-labeled chemical probes

22 May 2018

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

22 May 2018

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RAS oncogenes: weaving a tumorigenic web

22 May 2018

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The chemistry of bisphosphonates: from antiscaling agents to clinical therapeutics

22 May 2018

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Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab

22 May 2018

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Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics

22 May 2018

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Functional interrogation of the kinome using nucleotide acyl phosphates

22 May 2018

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Fluorinated phosphonates: synthesis and biomedical application

22 May 2018

1 reference

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Oncogenic Ras and its role in tumor cell invasion and metastasis

22 May 2018

1 reference

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The dark side of Ras: regulation of apoptosis

22 May 2018

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

22 May 2018

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Modulation of the immune response and tumor growth by activated Ras.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Down-regulation of the MHC class I antigen-processing machinery after oncogenic transformation of murine fibroblasts

22 May 2018

1 reference

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The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

22 May 2018

1 reference

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Stability constants of magnesium and cadmium complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of magnesium-ATP and magnesium-ADP

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs

22 May 2018

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The hydrolysis of uridine cyclic phosphonate catalyzed by ribonuclease-A: implications for the mechanism of action of the enzyme

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Sulfonylbenzoyl-nitrostyrenes: potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Function of Ras as a molecular switch in signal transduction

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5238463

Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression.

22 May 2018

1 reference

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Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

14 August 2018

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Rationally designed squaryldiamides – a novel class of sugar-nucleotide mimics?

14 August 2018

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Isoprenyl phosphinylformates: new inhibitors of squalene synthetase

30 November 2018

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12 December 2020

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors

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12 December 2020

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

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12 December 2020

The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway

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12 December 2020

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

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12 December 2020

Elevated ras oncogene expression correlates with lymph node metastases in breast cancer patients

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12 December 2020

10.1021/ACSMEDCHEMLETT.6B00373

Identifiers

DOI

1 reference

31 March 2018

PMC publication ID

5238463

1 reference

31 March 2018

PubMed publication ID

28105276

1 reference

31 March 2018