CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis. (Q51082157)

29 March 2018

title

CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis. (English)

1 reference

29 March 2018

1 reference

Grullich C

1

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29 March 2018

Sullards MC

2

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29 March 2018

Fuks Z

3

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29 March 2018

Merrill AH Jr

4

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29 March 2018

Kolesnick R

5

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29 March 2018

language of work or name

English

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publication date

1 March 2000

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29 March 2018

Journal of Biological Chemistry

published in

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29 March 2018

volume

275

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29 March 2018

issue

12

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29 March 2018

page(s)

8650-8656

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29 March 2018

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

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Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

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Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation

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Relationships of apoptotic signaling mediated by ceramide and TNF-alpha in U937 cells

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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Two CD95 (APO-1/Fas) signaling pathways

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Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway

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The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

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Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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Ceramide generation by the Reaper protein is not blocked by the caspase inhibitor, p35.

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal

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FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

21 January 2018

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

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Fas-induced apoptosis of T cells occurs independently of ceramide generation

21 January 2018

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Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis

21 January 2018

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FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

21 January 2018

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Ceramide in apoptosis--does it really matter?

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Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

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TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase

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Caspase-9 can be activated without proteolytic processing

21 January 2018

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Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation

21 January 2018

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Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

21 January 2018

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Suramin induced ceramide accumulation leads to apoptotic cell death in dorsal root ganglion neurons

21 January 2018

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Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.

21 January 2018

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Accumulation of glucosylceramides in multidrug-resistant cancer cells

21 January 2018

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Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

21 January 2018

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Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

21 January 2018

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CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition

21 January 2018

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Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells

21 January 2018

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Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation

21 January 2018

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Ceramide accumulation precedes caspase-dependent apoptosis in CHP-100 neuroepithelioma cells exposed to the protein phosphatase inhibitor okadaic acid

21 January 2018

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Induction of apoptotic DNA fragmentation and cell death by natural ceramide

21 January 2018

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Ceramide induces apoptosis in PC12 cells

21 January 2018

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Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts

21 January 2018

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Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling

21 January 2018

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Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways

21 January 2018

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Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase

21 January 2018

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Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.275.12.8650

1 reference

29 March 2018

1 reference

29 March 2018