Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice. (Q51016623)

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scientific article published on 4 March 2017

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English	Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice.	scientific article published on 4 March 2017

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scholarly article

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Europe PubMed Central

27 March 2018

http://europepmc.org/abstract/MED/28479002

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice (English)

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13 May 2020

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pulmonary fibrosis

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Martin Hauer-Jensen

12

object named as

Martin Hauer-Jensen

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Jin Pan

1

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Deguan Li

2

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Yanfeng Xu

3

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Junling Zhang

4

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Yueying Wang

5

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Mengyi Chen

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Shuai Lin

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Lan Huang

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Eun Joo Chung

9

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Deborah E Citrin

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Yingying Wang

11

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Daohong Zhou

13

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Aimin Meng

14

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13 May 2020

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publication date

4 March 2017

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27 March 2018

http://europepmc.org/abstract/MED/28479002

International Journal of Radiation Oncology Biology Physics

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99

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2

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353-361

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13 May 2020

Abnormal phenotype of cultured fibroblasts in human skin with chronic radiotherapy damage.

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https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total body irradiation selectively induces murine hematopoietic stem cell senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The senescence-associated secretory phenotype: the dark side of tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-induced and chemotherapy-induced pulmonary injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Telomere dysfunction causes alveolar stem cell failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of type II pneumocyte senescence in radiation-induced lung fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular senescence in aging and age-related disease: from mechanisms to therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular senescence: a double-edged sword in the fight against cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-induced lung injury. Assessment, management, and prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Senescence: a new weapon for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triptolide Mitigates Radiation-Induced Pulmonary Fibrosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging, cellular senescence, and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: cardiac and pulmonary late effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 alveolar cells are stem cells in adult lung.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation pulmonary toxicity: from mechanisms to management

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular senescence: from physiology to pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

1 reference

https://pubmed.ncbi.nlm.nih.gov/28479002

12 December 2020

based on heuristic

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Identifiers

10.1016/J.IJROBP.2017.02.216

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6853175&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6853175&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6853175&resulttype=core&format=json

13 May 2020

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