Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. (Q50624617)

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scientific article published on 16 September 2016

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English	Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.	scientific article published on 16 September 2016

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scholarly article

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23 March 2020

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity (English)

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23 March 2020

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23 March 2020

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23 March 2020

Munir Pirmohamed

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23 March 2020

author name string

Lee Faulkner

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23 March 2020

Andrew Sullivan

3

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23 March 2020

Toru Usui

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23 March 2020

Ana Alfirevic

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23 March 2020

Dean J Naisbitt

8

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23 March 2020

B Kevin Park

9

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23 March 2020

publication date

16 September 2016

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23 March 2020

Toxicological Sciences

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23 March 2020

154

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23 March 2020

2

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23 March 2020

416-429

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23 March 2020

Delayed drug hypersensitivity: models of T-cell stimulation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Avidity determines T-cell reactivity in abacavir hypersensitivity.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.

1 reference

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21 January 2018

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms

1 reference

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21 January 2018

Stimulation of human T cells with sulfonamides and sulfonamide metabolites.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

1 reference

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21 January 2018

Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base

1 reference

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21 January 2018

Medical genetics: a marker for Stevens-Johnson syndrome

1 reference

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21 January 2018

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Tracking human contact allergens: from mass spectrometric identification of peptide-bound reactive small chemicals to chemical-specific naive human T-cell priming

1 reference

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21 January 2018

Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

The development of in vitro culture methods to characterize primary T-cell responses to drugs

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Human leukocyte antigen-associated drug hypersensitivity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Comment on "Revised electron affinity of SF6 from kinetic data" [J. Chem. Phys. 136, 121102 (2012)].

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

PyPop update--a software pipeline for large-scale multilocus population genomics

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Abacavir-reactive memory T cells are present in drug naïve individuals

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

HLA-B*5701 screening for hypersensitivity to abacavir

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Drug hypersensitivity: pharmacogenetics and clinical syndromes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer

1 reference

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21 January 2018

Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Idiosyncratic adverse drug reactions: current concepts

1 reference

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21 January 2018

No association between HLA-B and cutaneous reactions to sulphonamides in human immunodeficiency virus-infected patients

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Promiscuous T-cell responses to drugs and drug-haptens

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW177

21 January 2018

Identifiers

10.1093/TOXSCI/KFW177

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27637899%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27637899%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

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