Caspase 2 (Q5049051)

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mammalian protein found in Homo sapiens

protein phosphatase 1, regulatory subunit 57
CASP2
neural precursor cell expressed developmentally down-regulated protein 2
caspase 2 apoptosis-related cysteine peptidase
caspase-2
protease ICH-1
NEDD-2

Language	Label	Description	Also known as
English	Caspase 2	mammalian protein found in Homo sapiens	protein phosphatase 1, regulatory subunit 57 CASP2 neural precursor cell expressed developmentally down-regulated protein 2 caspase 2 apoptosis-related cysteine peptidase caspase-2 protease ICH-1 NEDD-2

Statements

1 reference

13 November 2019

UniProt protein ID

0 references

caspase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

Peptidase C14, caspase non-catalytic subunit p10, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase family C14A, cysteine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

CARD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase C14, p20 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase C14A, caspase catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase family C14A, His active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein domain specific binding

determination method

1 reference

8 April 2019

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

protein binding

determination method

9 references

8 April 2019

RAIDD is a new 'death' adaptor molecule

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

determination method

1 reference

8 April 2019

Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

identical protein binding

determination method

3 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

determination method

cysteine-type endopeptidase activity

determination method

5 references

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

PAX2 suppresses apoptosis in renal collecting duct cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

cysteine-type endopeptidase activity involved in execution phase of apoptosis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

biological process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

determination method

1 reference

8 April 2019

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

execution phase of apoptosis

determination method

1 reference

8 April 2019

No death without life: vital functions of apoptotic effectors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

protein processing

determination method

1 reference

8 April 2019

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

positive regulation of apoptotic signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

cellular response to mechanical stimulus

determination method

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

positive regulation of neuron apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

brain development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

intrinsic apoptotic signaling pathway in response to DNA damage

determination method

1 reference

8 April 2019

No death without life: vital functions of apoptotic effectors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

PAX2 suppresses apoptosis in renal collecting duct cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

ectopic germ cell programmed cell death

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

neural retina development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

apoptotic process

determination method

3 references

5 June 2018

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

determination method

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

determination method

determination method

2 references

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

apoptotic process

determination method

4 references

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

determination method

physically interacts with

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL197672

Gene Atlas image

PBB GE CASP2 34449 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P42575

1 reference

Identifiers.org

Peptidase family C14A, His active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

Peptidase C14, p20 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

Peptidase C14A, caspase catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

Peptidase C14, caspase non-catalytic subunit p10

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

Peptidase family C14A, cysteine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42575

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000312664

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000312664

ENSP00000340030

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340030

ENSP00000376656

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376656

ENSP00000481929

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481929

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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