Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery. (Q50420935)

http://europepmc.org/abstract/MED/29503208

13 March 2018

title

Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery. (English)

1 reference

http://europepmc.org/abstract/MED/29503208

13 March 2018

1 reference

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sepp Hochreiter

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

10

Peter Buijnsters

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Jaak Simm

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Günter Klambauer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Adam Arany

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Marvin Steijaert

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Jörg Kurt Wegner

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Emmanuel Gustin

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Vladimir Chupakhin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Yolanda T Chong

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Jorge Vialard

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Ingrid Velter

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Alexander Vapirev

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Shantanu Singh

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Anne E Carpenter

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Yves Moreau

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Hugo Ceulemans

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

publication date

16 February 2018

1 reference

http://europepmc.org/abstract/MED/29503208

13 March 2018

published in

Cell chemical biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

611-618.e3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

Applications in image-based profiling of perturbations

5 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

In silico ADME/T modelling for rational drug design.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Reliable estimation of prediction errors for QSAR models under model uncertainty using double cross-validation

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Increasing the Content of High-Content Screening: An Overview

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Multiplex cytological profiling assay to measure diverse cellular states

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Chemical predictive modelling to improve compound quality

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Imaged-based high-throughput screening for anti-angiogenic drug discovery

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Extended-connectivity fingerprints

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Visualization of image data from cells to organisms

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

The potential of high-content high-throughput microscopy in drug discovery

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

High-throughput fluorescence microscopy for systems biology

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

In silico prediction of blood brain barrier permeability: an Artificial Neural Network model.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Phenotypic screening of small molecule libraries by high throughput cell imaging

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6031326

Prediction of drug absorption using multivariate statistics

8 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29503208

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Application of random forest approach to QSAR prediction of aquatic toxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29503208

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2018.01.015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29503208%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference