NAD+ in Aging: Molecular Mechanisms and Translational Implications. (Q50128435)

http://europepmc.org/abstract/MED/28899755

25 February 2018

title

NAD+ in Aging: Molecular Mechanisms and Translational Implications. (English)

1 reference

http://europepmc.org/abstract/MED/28899755

25 February 2018

author

Evandro F Fang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Yujun Hou

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

7

Vilhelm A Bohr

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

6

Mark P Mattson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Sofie Lautrup

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Tyler G Demarest

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Deborah L Croteau

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

9 September 2017

1 reference

http://europepmc.org/abstract/MED/28899755

25 February 2018

published in

Trends in Molecular Medicine

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

23

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13 June 2020

issue

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

899-916

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28899755%20AND%20SRC:MED&resulttype=core&format=json

The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study.

13 June 2020

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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

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Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration

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The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.

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Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease.

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NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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Do DNA Double-Strand Breaks Drive Aging?

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NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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Life span extension and neuronal cell protection by Drosophila nicotinamidase

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AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation

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Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

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FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment

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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

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Elevation of blood NAD level after moderate exercise in young women and mice.

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Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

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Increased radioprotection attained by DNA repair enhancement

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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12 December 2020

Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice.

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12 December 2020

An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

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12 December 2020

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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12 December 2020

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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12 December 2020

Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

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12 December 2020

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

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XPA: A key scaffold for human nucleotide excision repair

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In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

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12 December 2020

Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation

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12 December 2020

Cockayne syndrome: Clinical features, model systems and pathways

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12 December 2020

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

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12 December 2020

Self-consumption: the interplay of autophagy and apoptosis

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12 December 2020

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

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12 December 2020

NAD+ as a metabolic link between DNA damage and cell death.

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12 December 2020

Three complementation groups in Cockayne syndrome

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12 December 2020

SIRT1 activation confers neuroprotection in experimental optic neuritis

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12 December 2020

DNA Damage, DNA Repair, Aging, and Neurodegeneration

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12 December 2020

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

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12 December 2020

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

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12 December 2020

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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12 December 2020

NAD+ and sirtuins in aging and disease

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12 December 2020

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

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12 December 2020

The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing

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12 December 2020

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

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12 December 2020

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

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12 December 2020

Biosensor reveals multiple sources for mitochondrial NAD⁺.

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12 December 2020

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

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12 December 2020

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans

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12 December 2020

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

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12 December 2020

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

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12 December 2020

A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis

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12 December 2020

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

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12 December 2020

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

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12 December 2020

Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

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12 December 2020

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

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12 December 2020

Sirtuins at a glance.

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12 December 2020

Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease

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12 December 2020

CD38 Knockout Mice Show Significant Protection Against Ischemic Brain Damage Despite High Level Poly-ADP-Ribosylation

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12 December 2020

Fasting: molecular mechanisms and clinical applications

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12 December 2020

Nicotinamide adenine dinucleotide (NADH)--a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral application

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12 December 2020

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

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12 December 2020

The multifaceted functions of sirtuins in cancer

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12 December 2020

Nicotinamide adenine dinucleotide: An essential factor in preserving hearing in cisplatin-induced ototoxicity

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12 December 2020

Environmental noise pollution in the United States: developing an effective public health response

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12 December 2020

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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12 December 2020

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

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12 December 2020

Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss

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12 December 2020

Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons

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12 December 2020

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.

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12 December 2020

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

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12 December 2020

The first human clinical study for NMN has started in Japan

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12 December 2020

Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.

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12 December 2020

Regulation of intracellular levels of NAD: a novel role for CD38.

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12 December 2020

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

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12 December 2020

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

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12 December 2020

NAD⁺ in aging, metabolism, and neurodegeneration.

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12 December 2020

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

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12 December 2020

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model

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12 December 2020

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

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12 December 2020

Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease.

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12 December 2020

Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment

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12 December 2020

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

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12 December 2020

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.

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12 December 2020

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

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12 December 2020

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

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12 December 2020

Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model.

1 reference

12 December 2020

SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

1 reference

12 December 2020

A microarray-based genetic screen for yeast chronological aging factors

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12 December 2020

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.

1 reference

12 December 2020

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

1 reference

12 December 2020

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

1 reference

12 December 2020

Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.

1 reference

12 December 2020

Safety assessment of nicotinamide riboside, a form of vitamin B3

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12 December 2020

Nuclear DNA damage signalling to mitochondria in ageing

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12 December 2020

Mitochondria and cancer

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12 December 2020

The NAD+ precursor nicotinic acid improves genomic integrity in human peripheral blood mononuclear cells after X-irradiation

1 reference

12 December 2020

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.

1 reference

12 December 2020

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

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12 December 2020

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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12 December 2020

Compromised autophagy and neurodegenerative diseases

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12 December 2020