Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism. (Q50071437)

24 February 2018

http://europepmc.org/abstract/MED/29125572

title

Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6150307&resulttype=core&format=json

12 May 2020

Silybum marianum

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6150307&resulttype=core&format=json

12 May 2020

author name string

Michal Bijak

series ordinal

1

1 reference

24 February 2018

http://europepmc.org/abstract/MED/29125572

language of work or name

English

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publication date

10 November 2017

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24 February 2018

http://europepmc.org/abstract/MED/29125572

published in

Molecules

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6150307&resulttype=core&format=json

12 May 2020

volume

22

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6150307&resulttype=core&format=json

12 May 2020

issue

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6150307&resulttype=core&format=json

Creative Commons Attribution 4.0 International

12 May 2020

copyright license

start time

10 November 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.

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Flavonolignans inhibit ADP induced blood platelets activation and aggregation in whole blood.

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Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and Leukocytes

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Mechanistic study of the biomimetic synthesis of flavonolignan diastereoisomers in milk thistle

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HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case

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Molecular Structure and Stereochemistry of Silybin A, Silybin B, Isosilybin A, and Isosilybin B, Isolated from Silybum marianum (Milk Thistle)

21 January 2018

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Enzymatic kinetic resolution of silybin diastereoisomers

21 January 2018

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New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum

21 January 2018

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An updated systematic review with meta-analysis for the clinical evidence of silymarin

21 January 2018

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Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

21 January 2018

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Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

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The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity

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Silybin is metabolized by cytochrome P450 2C8 in vitro.

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Application of liquid chromatography-electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes

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Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C

21 January 2018

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Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles

21 January 2018

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Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system

21 January 2018

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Solid state mechanochemical activation of Silybum marianum dry extract with betacyclodextrins: Characterization and bioavailability of the coground systems.

21 January 2018

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Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects

21 January 2018

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Development of a HPLC-UV assay for silybin-phosphatidylcholine complex (silybinin capsules) and its pharmacokinetic study in healthy male Chinese volunteers.

21 January 2018

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The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell

21 January 2018

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Bile Salt/Lecithin Mixed Micelles Optimized for the Solubilization of a Poorly Soluble Steroid Molecule Using Statistical Experimental Design

21 January 2018

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Membranolytic activity of bile salts: influence of biological membrane properties and composition.

21 January 2018

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Enhanced oral bioavailability of silymarin using liposomes containing a bile salt: preparation by supercritical fluid technology and evaluation in vitro and in vivo

21 January 2018

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Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate

21 January 2018

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Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound

21 January 2018

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21 January 2018

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21 January 2018

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Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability

21 January 2018

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Formulation and biopharmaceutical evaluation of silymarin using SMEDDS.

21 January 2018

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Stability studies of silymarin nanoemulsion containing Tween 80 as a surfactant

21 January 2018

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Comparative bioavailability of Silipide, a new flavanolignan complex, in rats

21 January 2018

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12 December 2020

Media effects on the mechanism of antioxidant action of silybin and 2,3-dehydrosilybin: role of the enol group

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12 December 2020

Protective effect of Legalon in workers exposed to organic solvents.

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12 December 2020

Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application

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12 December 2020

In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery

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12 December 2020

Comparative pharmacokinetics of silipide and silymarin in rats

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12 December 2020

Polyphenol compounds belonging to flavonoids inhibit activity of coagulation factor X

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12 December 2020

Chemoenzymatic preparation of silybin beta-glucuronides and their biological evaluation

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12 December 2020

Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures

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12 December 2020

Milk thistle: Silybum marianum.

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12 December 2020

Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies

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12 December 2020

Silybin and silymarin--new effects and applications

1 reference

12 December 2020

Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay

1 reference

12 December 2020

Two high-performance liquid chromatographic assays for the determination of free and total silibinin diastereomers in plasma using column switching with electrochemical detection and reversed-phase chromatography with ultraviolet detection

1 reference

12 December 2020

Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry

1 reference

12 December 2020

Intestinal transport of bile acids

1 reference

12 December 2020

A new inclusion complex of silibinin and beta-cyclodextrins: in vitro dissolution kinetics and in vivo absorption in comparison with traditional formulations

1 reference

12 December 2020

A novel solid dispersion system for natural product-loaded medicine: silymarin-loaded solid dispersion with enhanced oral bioavailability and hepatoprotective activity

1 reference

12 December 2020

[Liver-protective action of silymarin therapy in chronic alcoholic liver diseases]

1 reference

12 December 2020

Influence of silybin on biophysical properties of phospholipid bilayers

1 reference

12 December 2020

Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes

1 reference

12 December 2020

1 reference

12 December 2020

Determinants of intestinal mucosal uptake of short- and medium-chain fatty acids and alcohols

1 reference

12 December 2020

Stereoselective metabolism of silybin diastereoisomers in the glucuronidation process

1 reference

12 December 2020

Bioavailability of a silybin-phosphatidylcholine complex in dogs

1 reference

12 December 2020

Effect of silymarin on chemical, functional, and morphological alterations of the liver. A double-blind controlled study

1 reference

12 December 2020

Reassessing bioavailability of silymarin.

1 reference

12 December 2020

Pharmacokinetic studies with silymarin in human serum and bile

1 reference

12 December 2020

[Flavonolignans - compounds not only for liver treatment].

1 reference

12 December 2020

Comparative bioavailability of silibinin in healthy male volunteers.

1 reference

12 December 2020

10.3390/MOLECULES22111942

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6150307&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6150307&resulttype=core&format=json

12 May 2020

1 reference