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Jun proto-oncogene, AP-1 transcription factor subunit (Q5005943)

From Wikidata
mammalian protein found in Homo sapiens
  • JUN
  • p39
  • Jun activation domain binding protein
  • enhancer-binding protein AP1
  • v-jun sarcoma virus 17 oncogene homolog
  • transcription factor AP-1
  • activator protein 1
  • jun oncogene
  • AP1
  • proto-oncogene cJun
  • proto-oncogene c-Jun
  • v-jun avian sarcoma virus 17 oncogene homolog
  • Proto-Oncogene Proteins c-jun
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    English
    Jun proto-oncogene, AP-1 transcription factor subunit
    mammalian protein found in Homo sapiens
    • JUN
    • p39
    • Jun activation domain binding protein
    • enhancer-binding protein AP1
    • v-jun sarcoma virus 17 oncogene homolog
    • transcription factor AP-1
    • activator protein 1
    • jun oncogene
    • AP1
    • proto-oncogene cJun
    • proto-oncogene c-Jun
    • v-jun avian sarcoma virus 17 oncogene homolog
    • Proto-Oncogene Proteins c-jun

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    37 references
    retrieved
    8 April 2019
    stated in
    The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TAF7 (TAFII55) plays a role in the transcription activation by c-Jun
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    UNC-16, a JNK-Signaling Scaffold Protein, Regulates Vesicle Transport in C. elegans
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The tyrosine kinase Syk regulates TPL2 activation signals
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN).
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human MAP kinase interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The protein interaction landscape of the human CMGC kinase group
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Visualization of AP-1 NF-kappaB ternary complexes in living cells by using a BiFC-based FRET.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IPI
    DNA-binding transcription factor activity, RNA polymerase II-specific
    determination method or standard
    IBA
    IC
    IDA
    ISA
    ISM
    NAS
    7 references
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    ISM
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    ISA
    retrieved
    8 April 2019
    stated in
    Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    cJun modulates Ggamma-globin gene expression via an upstream cAMP response element
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IC
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IBA
    cell component
    biological process
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IC
    IDA
    IEA
    5 references
    retrieved
    17 October 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
    determination method or standard
    IEA
    retrieved
    17 October 2017
    stated in
    Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    cJun modulates Ggamma-globin gene expression via an upstream cAMP response element
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
    determination method or standard
    IC
    positive regulation of transcription, DNA-templated
    determination method or standard
    IDA
    IEA
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IBA
    IDA
    IEA
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
    GOA
    curator
    UniProt
    UniProt protein ID
    P05412
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    cJun modulates Ggamma-globin gene expression via an upstream cAMP response element
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
    determination method or standard
    IBA
    Gene Atlas image
    PBB GE JUN 201464 x at fs.png
    732 × 530; 12 KB
    0 references
    Commons category
    Transcription factor Jun
    0 references

    Identifiers

    MeSH descriptor ID
    D016755
    subject named as
    Proto-Oncogene Proteins c-jun
    0 references
    Freebase ID
    /m/02py1gd
    0 references
     
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q5005943&oldid=2450100098"