Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection. (Q50042606)

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scientific article published on 10 May 2011

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English	Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection.	scientific article published on 10 May 2011

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Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection (English)

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Salmonella Typhimurium

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Constatino III Roberto López Macías

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Constatino III Roberto López Macías

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Robert A Kingsley

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses

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Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1.

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CD4+-T-cell responses generated during murine Salmonella enterica serovar Typhimurium infection are directed towards multiple epitopes within the natural antigen FliC

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Method for the isolation of highly purified Salmonella flagellins

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