Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress. (Q50027676)

23 February 2018

title

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress. (English)

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23 February 2018

author name string

Ronald C Wek

series ordinal

1

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23 February 2018

publication date

12 February 2018

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23 February 2018

Cold Spring Harbor Perspectives in Biology

published in

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23 February 2018

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control

cites work

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12 December 2020

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

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12 December 2020

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

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12 December 2020

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

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12 December 2020

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

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12 December 2020

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Perk is essential for translational regulation and cell survival during the unfolded protein response

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12 December 2020

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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12 December 2020

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

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12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

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12 December 2020

The protein kinase Gcn2p mediates sodium toxicity in yeast

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12 December 2020

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

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12 December 2020

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

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12 December 2020

Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter

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12 December 2020

Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter

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12 December 2020

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

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12 December 2020

Activation of GCN2 in UV-irradiated cells inhibits translation

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12 December 2020

Mouse Atf5: molecular cloning of two novel mRNAs, genomic organization, and odorant sensory neuron localization.

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12 December 2020

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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12 December 2020

The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.

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12 December 2020

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

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12 December 2020

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity

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12 December 2020

YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed

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12 December 2020

Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis

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12 December 2020

Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

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12 December 2020

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

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12 December 2020

GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation

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12 December 2020

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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12 December 2020

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

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12 December 2020

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

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12 December 2020

uAUG and uORFs in human and rodent 5'untranslated mRNAs

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12 December 2020

The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism

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12 December 2020

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

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12 December 2020

IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation

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12 December 2020

Translational regulation of GCN4 and the general amino acid control of yeast

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12 December 2020

Endoplasmic reticulum stress signaling in disease

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12 December 2020

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

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12 December 2020

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory

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12 December 2020

The role of p58IPK in protecting the stressed endoplasmic reticulum

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12 December 2020

Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region

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12 December 2020

Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

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12 December 2020

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

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12 December 2020

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

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12 December 2020

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

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12 December 2020

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation

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12 December 2020

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

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12 December 2020

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

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12 December 2020

Evolution of alternative and constitutive regions of mammalian 5'UTRs.

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12 December 2020

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

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12 December 2020

Blocking UV-induced eIF2alpha phosphorylation with small molecule inhibitors of GCN2.

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12 December 2020

Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p

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12 December 2020

Translational control of protein kinase Ceta by two upstream open reading frames

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12 December 2020

Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease

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12 December 2020

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

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12 December 2020

BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

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12 December 2020

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response

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12 December 2020

The binary switch that controls the life and death decisions of ER stressed β cells

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12 December 2020

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

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12 December 2020

Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response

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12 December 2020

The unfolded protein response: from stress pathway to homeostatic regulation

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12 December 2020

Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice

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12 December 2020

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

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12 December 2020

Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

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12 December 2020

Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response

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12 December 2020

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

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12 December 2020

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

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12 December 2020

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

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12 December 2020

A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS).

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12 December 2020

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

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12 December 2020

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

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12 December 2020

Pharmacological brake-release of mRNA translation enhances cognitive memory

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12 December 2020

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

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12 December 2020

Stress granules and cell signaling: more than just a passing phase?

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12 December 2020

EIF2AK4 mutations in pulmonary capillary hemangiomatosis

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12 December 2020

Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder

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12 December 2020

EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension.

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12 December 2020

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

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12 December 2020

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications

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12 December 2020

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα.

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12 December 2020

Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells

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12 December 2020

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

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12 December 2020

The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum

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12 December 2020

Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration

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12 December 2020

Translation of 5' leaders is pervasive in genes resistant to eIF2 repression

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12 December 2020

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

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12 December 2020

Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.

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12 December 2020

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

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12 December 2020

Diversity and selectivity in mRNA translation on the endoplasmic reticulum

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12 December 2020

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

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12 December 2020

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

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12 December 2020

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound

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12 December 2020

Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response

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12 December 2020

N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency

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12 December 2020

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

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12 December 2020

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

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12 December 2020

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

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12 December 2020

Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability

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12 December 2020

Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response

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12 December 2020

Dynamic m(6)A mRNA methylation directs translational control of heat shock response

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12 December 2020

5' UTR m(6)A Promotes Cap-Independent Translation

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12 December 2020

Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response

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12 December 2020

Translation from the 5' untranslated region shapes the integrated stress response

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12 December 2020

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.

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12 December 2020

Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons

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12 December 2020

Infantile Cirrhosis, Growth Impairment, and Neurodevelopmental Anomalies Associated with Deficiency of PPP1R15B.

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12 December 2020

EIF2AK4 mutation as "second hit" in hereditary pulmonary arterial hypertension

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12 December 2020

Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.

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12 December 2020

EIF2AK4 Mutations in Patients Diagnosed With Pulmonary Arterial Hypertension.

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12 December 2020

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling.

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12 December 2020

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

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12 December 2020

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157.

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12 December 2020

Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2.

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12 December 2020

Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

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12 December 2020

Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.

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12 December 2020

IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation

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12 December 2020

10.1101/CSHPERSPECT.A032870

Identifiers

DOI

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23 February 2018

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23 February 2018