Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase. (Q49949161)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348809%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase (English)

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9 April 2020

3

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9 April 2020

author name string

Danqing Feng

1

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9 April 2020

Tesfaye Biftu

2

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9 April 2020

Ahmet Kekec

4

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9 April 2020

James Dropinski

5

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9 April 2020

Andrew Kassick

6

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9 April 2020

Shiyao Xu

7

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9 April 2020

Marc M Kurtz

8

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9 April 2020

Anantha Gollapudi

9

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9 April 2020

Qing Shao

10

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9 April 2020

Xiaodong Yang

11

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9 April 2020

Ku Lu

12

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9 April 2020

Gaochao Zhou

13

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9 April 2020

Daniel Kemp

14

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9 April 2020

Robert W Myers

15

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9 April 2020

Hong-Ping Guan

16

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9 April 2020

Maria E Trujillo

17

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9 April 2020

Cai Li

18

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9 April 2020

Ann Weber

19

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9 April 2020

Iyassu K Sebhat

20

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9 April 2020

publication date

1 December 2017

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ACS Medicinal Chemistry Letters

9 April 2020

published in

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volume

9

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9 April 2020

issue

1

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9 April 2020

page(s)

39-44

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Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.

9 April 2020

cites work

1 reference

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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.

8 September 2018

1 reference

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Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators

8 September 2018

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Type 2 Diabetes Medication Review

8 September 2018

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Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases

8 September 2018

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AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels

8 September 2018

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AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

8 September 2018

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Structural basis of AMPK regulation by small molecule activators

8 September 2018

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

8 September 2018

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Exercise, GLUT4, and skeletal muscle glucose uptake

8 September 2018

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AMPK and Exercise: Glucose Uptake and Insulin Sensitivity.

8 September 2018

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A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

8 September 2018

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AMPK in Health and Disease

8 September 2018

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AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

8 September 2018

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Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial.

8 September 2018

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AMP-activated protein kinase in the heart: role during health and disease

8 September 2018

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5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes.

8 September 2018

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Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle

8 September 2018

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10.1021/ACSMEDCHEMLETT.7B00417

8 September 2018

Identifiers

DOI

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9 April 2020

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9 April 2020

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