Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. (Q48971205)

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12 January 2020

title

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies (English)

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Anny Devoy

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Lynn Bedford

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David Hay

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Nooshin Rezvani

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Tim Soane

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Paul W Sheppard

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Dmitry Usoskin

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James Lowe

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R John Mayer

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language of work or name

English

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publication date

1 August 2008

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12 January 2020

published in

Journal of Neuroscience

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volume

28

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page(s)

8189-8198

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issue

33

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Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis

12 January 2020

cites work

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12 December 2020

The 26S proteasome: a molecular machine designed for controlled proteolysis

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12 December 2020

A gated channel into the proteasome core particle

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12 December 2020

In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies

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12 December 2020

Aggregation chimeras. Combining ES cells, diploid and tetraploid embryos.

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12 December 2020

The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

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Parkin and the molecular pathways of Parkinson's disease

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12 December 2020

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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12 December 2020

Analysis of Drosophila 26 S proteasome using RNA interference

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12 December 2020

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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12 December 2020

Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene

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12 December 2020

A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

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12 December 2020

Recruitment of a 19S proteasome subcomplex to an activated promoter

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12 December 2020

Proteasome subunit Rpn1 binds ubiquitin-like protein domains

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12 December 2020

Substrate access and processing by the 20S proteasome core particle

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12 December 2020

Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes

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12 December 2020

Relationships between Lewy bodies and pale bodies in Parkinson's disease.

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12 December 2020

Proteasomes and their kin: proteases in the machine age

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12 December 2020

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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12 December 2020

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

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12 December 2020

Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus

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12 December 2020

Identification and characterization of a Drosophila proteasome regulatory network

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12 December 2020

Ubiquitin and ubiquitin-like proteins as multifunctional signals

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12 December 2020

Molecular pathogenesis of Parkinson's disease

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12 December 2020

Proteasome-associated proteins: regulation of a proteolytic machine

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12 December 2020

ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.

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12 December 2020

Toxin-induced models of Parkinson's disease

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12 December 2020

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12 December 2020

Expanding insights of mitochondrial dysfunction in Parkinson's disease.

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A decade of modeling Alzheimer's disease in transgenic mice.

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12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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12 December 2020

Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Parkinson's disease: a rethink of rodent models.

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12 December 2020

Widespread, but non-identical, association of proteasomal 19 and 20 S proteins with yeast chromatin.

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12 December 2020

Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

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12 December 2020

Protective roles for induction of autophagy in multiple proteinopathies

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12 December 2020

Emerging roles for ubiquitin and protein degradation in neuronal function

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12 December 2020

Proteasomes: machines for all reasons

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12 December 2020

Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells

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12 December 2020

Global changes to the ubiquitin system in Huntington's disease.

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12 December 2020

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry

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12 December 2020

Progranulin: normal function and role in neurodegeneration

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12 December 2020

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

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12 December 2020

The PINK1/Parkin pathway regulates mitochondrial morphology

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12 December 2020

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene

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12 December 2020

Autophagy fights disease through cellular self-digestion

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12 December 2020

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

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12 December 2020

Immunogold localisation of ubiquitin-protein conjugates in primary (azurophilic) granules of polymorphonuclear neutrophils

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12 December 2020

Proteasome subunit Rpn13 is a novel ubiquitin receptor

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12 December 2020

The central unit within the 19S regulatory particle of the proteasome

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12 December 2020

In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain.

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12 December 2020

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodie

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12 December 2020

Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse.

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12 December 2020

Defective mitosis due to a mutation in the gene for a fission yeast 26S proteasesubunit

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12 December 2020

Characteristics of 26 S proteases from fission yeast mutants, which arrest in mitosis.

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12 December 2020

Control of memory formation through regulated expression of a CaMKII transgene

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12 December 2020

Subregion- and cell type-restricted gene knockout in mouse brain

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12 December 2020

Structure of 20S proteasome from yeast at 2.4 A resolution

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12 December 2020

Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

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12 December 2020

Aggresomes: a cellular response to misfolded proteins

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12 December 2020

10.1523/JNEUROSCI.2218-08.2008

Identifiers

DOI

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