Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. (Q48873577)

http://europepmc.org/abstract/PMC/5868285

28 June 2018

title

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. (English)

1 reference

http://europepmc.org/abstract/PMC/5868285

28 June 2018

0 references

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Caroline Verbeke

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Thomas Gress

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

E Hessmann

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

M S Patzak

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

L Klein

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

N Chen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

V Kari

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

I Ramu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

T E Bapiro

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

K K Frese

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

A Gopinathan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

F M Richards

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

D I Jodrell

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

X Li

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

R Heuchel

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

J M Löhr

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

V Ellenrieder

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

A Neesse

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

0 references

publication date

10 January 2017

1 reference

http://europepmc.org/abstract/PMC/5868285

28 June 2018

published in

Gut

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

67

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

497-507

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

Metastatic progression is associated with dynamic changes in the local microenvironment

9 June 2020

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1 reference

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30 June 2018

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30 June 2018

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Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

30 June 2018

1 reference

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Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.

30 June 2018

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T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma

30 June 2018

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SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial

30 June 2018

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30 June 2018

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Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

30 June 2018

1 reference

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Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

30 June 2018

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30 June 2018

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1 reference

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Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

30 June 2018

1 reference

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Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy

30 June 2018

1 reference

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Stromal reengineering to treat pancreas cancer

30 June 2018

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Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

30 June 2018

1 reference

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Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

30 June 2018

1 reference

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Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

30 June 2018

1 reference

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Transport properties of pancreatic cancer describe gemcitabine delivery and response

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

30 June 2018

1 reference

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Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine

30 June 2018

1 reference

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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

30 June 2018

1 reference

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SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Stromal disrupting effects of nab-paclitaxel in pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer

30 June 2018

1 reference

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CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer

30 June 2018

1 reference

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

30 June 2018

1 reference

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The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

30 June 2018

1 reference

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Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5868285

Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28077438

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28077438

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28077438

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1136/GUTJNL-2016-311954

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28077438%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

28077438

1 reference