Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. (Q48706959)

http://europepmc.org/abstract/MED/9133382

14 February 2018

title

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. (English)

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http://europepmc.org/abstract/MED/9133382

14 February 2018

0 references

I Vincent

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

G Jicha

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

M Rosado

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

D W Dickson

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

language of work or name

English

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publication date

1 May 1997

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http://europepmc.org/abstract/MED/9133382

14 February 2018

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

volume

17

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

page(s)

3588-3598

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15 May 2020

issue

10

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Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.

15 May 2020

cites work

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12 December 2020

Proline-directed protein phosphorylation and cell cycle regulation

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Association of type II cAMP-dependent protein kinase with p34cdc2 protein kinase in human fibroblasts

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Immunohistochemical evidence for apoptosis in Alzheimer's disease.

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Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

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Cell death and the cell cycle: a relationship between transformation and neurodegeneration?

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Neuropathological stageing of Alzheimer-related changes

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Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells

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In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes

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Neuronal cdc2-like kinase

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Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement

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A study of apoptosis in normal and pathologic nervous tissue after in situ end-labeling of DNA strand breaks

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Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

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Purification of a 15-kDa cdk4- and cdk5-binding protein.

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Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

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Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage

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Cell cycle regulation of a Xenopus Wee1-like kinase

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Downregulation of CDC2 upon terminal differentiation of neurons

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Activation of cyclin A-dependent protein kinases during apoptosis

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Cyclin activation of p34cdc2.

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Apoptosis in the brain. Physiology and pathology

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Proline-directed kinase systems in Alzheimer's disease pathology.

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Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice.

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DNA synthesis and cell division in the adult primate brain

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Evidence for apoptotic cell death in Alzheimer's disease.

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cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor

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Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

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Mitotic mechanisms in Alzheimer's disease?

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Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias

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Requirement for a functional Rb-1 gene in murine development

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RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis.

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Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

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Platelet-activating factor- and thrombin-induced stimulation of p34cdc2-cyclin histone H1 kinase activity in platelets

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12 December 2020

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

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12 December 2020

Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death

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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

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12 December 2020

Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation

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Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.

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12 December 2020

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state

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12 December 2020

Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.

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12 December 2020

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

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12 December 2020

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

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A family of human cdc2-related protein kinases

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12 December 2020

Cdc2 regulatory factors

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12 December 2020

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

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12 December 2020

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

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12 December 2020

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase

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12 December 2020

Premature p34cdc2 activation required for apoptosis.

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12 December 2020

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

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12 December 2020

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

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12 December 2020

Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons

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12 December 2020

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

1 reference

12 December 2020

Death by suicide: one way to go in mammalian cellular development?

1 reference

12 December 2020

10.1523/JNEUROSCI.17-10-03588.1997

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6573674&resulttype=core&format=json

15 May 2020

1 reference