Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats. (Q48663701)

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scientific article published on 11 February 2012

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English	Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats.	scientific article published on 11 February 2012

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scholarly article

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats. (English)

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

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ChEBI release 2020-05-28

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Gabriel R. Fries

4

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

6

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

Flávio Kapczinski

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object named as

Flávio Kapczinski

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Europe PubMed Central

14 February 2018

Gislaine Zilli Réus

1

object named as

Gislaine Z Réus

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

Roberto B Stringari

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object named as

Roberto B Stringari

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

Helena Mendes Abelaira

2

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Helena M Abelaira

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14 February 2018

http://europepmc.org/abstract/MED/22327556

publication date

11 February 2012

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

Metabolic Brain Disease

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

27

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

2

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

175-182

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Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

https://scigraph.springernature.com/pub.10.1007/s11011-012-9281-2

0 references

Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats

1 reference

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Evidence for the involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice

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Neurotrophins and depression

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Antidepressant effects of ketamine in depressed patients

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Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

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Anhedonia and activity deficits in rats: impact of post-stroke depression

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Creatine kinase levels in patients with bipolar disorder: depressive, manic, and euthymic phases.

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An open-label, flexible-dose study of memantine in major depressive disorder.

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Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties

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Chronic administration of ketamine elicits antidepressant-like effects in rats without affecting hippocampal brain-derived neurotrophic factor protein levels

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21 January 2018

Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats.

1 reference

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Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry

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The role of glutamate on the action of antidepressants

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Adult brain neurogenesis and psychiatry: a novel theory of depression

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An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons.

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Memantine attenuates staurosporine-induced activation of caspase-3 and LDH release in mouse primary neuronal cultures

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Mechanism of action of memantine

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Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs.

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Animal models and human depressive disorders

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Predictability of chronic intermittent stress: effects on sympathetic-adrenal medullary responses of laboratory rats

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The molecular neurobiology of depression

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Neurotrophic factors: from molecule to man.

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Chronic mild stress paradigm reduces sweet food intake in rats without affecting brain derived neurotrophic factor protein levels

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Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm

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Effects of chronic mild stress on the oxidative parameters in the rat brain.

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N-acetylcysteine for major depressive episodes in bipolar disorder

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Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors

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The cellular neurobiology of depression

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The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain

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Potential antidepressive properties of amantadine, memantine and bifemelane

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Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-D-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells

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Neurobiology of depression

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The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia

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Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

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Stress, depression, and neuroplasticity: a convergence of mechanisms

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Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model.

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The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

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Pharmacodynamics of memantine: an update

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Acute treatment with low doses of memantine does not impair aversive, non-associative and recognition memory in rats.

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Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?

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1 reference

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12 December 2020

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Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327556

12 December 2020

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Neuroimaging Abnormalities in the Amygdala in Mood Disorders

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Correlation between plasma levels of glutamate, alanine and serine with severity of depression

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Protein measurement with the Folin phenol reagent

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https://pubmed.ncbi.nlm.nih.gov/22327556

12 December 2020

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Interaction of BDNF/TrkB signaling with NMDA receptor in learning and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327556

12 December 2020

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Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats

1 reference

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12 December 2020

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Childhood and adolescent depression: why do children and adults respond differently to antidepressant drugs?

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Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate

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https://pubmed.ncbi.nlm.nih.gov/22327556

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Increased serum glutamate in depressed patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11011-012-9281-2

1 reference

Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

1 reference

Europe PubMed Central

14 February 2018

http://europepmc.org/abstract/MED/22327556

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