Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. (Q48468481)

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scientific article published on 15 October 2002

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English	Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.	scientific article published on 15 October 2002

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13 December 2019

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis (English)

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13 December 2019

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Peter Henry St George-Hyslop

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McLaurin J

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Cecal R

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Kierstead ME

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Tian X

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Phinney AL

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Manea M

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French JE

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Lambermon MH

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Darabie AA

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Brown ME

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Janus C

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Chishti MA

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Horne P

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Westaway D

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Fraser PE

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Mount HT

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Przybylski M

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15 October 2002

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Nature Medicine

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1263-1269

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13 December 2019

https://scigraph.springernature.com/pub.10.1038/nm790

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Alzheimer's disease and Abeta toxicity: from top to bottom

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody.

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Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

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APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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13 December 2019

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13 December 2019

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