Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. (Q48448837)

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14 December 2019

title

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice (English)

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14 December 2019

author name string

Orly Lazarov

1

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14 December 2019

Michael Lee

2

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14 December 2019

Daniel A Peterson

3

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14 December 2019

Sangram S Sisodia

4

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14 December 2019

language of work or name

English

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publication date

1 November 2002

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14 December 2019

published in

Journal of Neuroscience

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14 December 2019

volume

22

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14 December 2019

page(s)

9785-9793

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14 December 2019

issue

22

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Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

14 December 2019

cites work

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

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Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease

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The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

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Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

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Entorhinal cortex pathology in Alzheimer's disease

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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Deposition of ?/A4 protein along neuronal plasma membranes in diffuse senile plaques

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Amyloid precursor protein in aged nonhuman primates

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Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation.

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Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities.

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Identification of the cells of origin of a central pathway which sprouts following lesions in mature rats

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Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat.

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Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve

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Projection of the entorhinal layer II neurons in the rat as revealed by intracellular pressure-injection of neurobiotin

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Intraneuronal compartments of the amyloid precursor protein.

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Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

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Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions

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Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Evolution of the neuropathology of Alzheimer's disease.

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12 December 2020

Dystrophic neurite formation associated with age-related beta amyloid deposition in the neocortex: clues to the genesis of neurofibrillary pathology.

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

Transgenic models of neurodegenerative diseases

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Sprouting in the hippocampus is layer-specific

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12 December 2020

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

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12 December 2020

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

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12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

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12 December 2020

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

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12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

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12 December 2020

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

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12 December 2020

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

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12 December 2020

Mutant genes in familial Alzheimer's disease and transgenic models

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12 December 2020

Morphological features of the entorhinal-hippocampal connection.

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12 December 2020

Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals

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12 December 2020

Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat

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12 December 2020

Reinnervation of dentate gyrus by homologous afferents following entorhinal cortical lesions in adult rats

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12 December 2020

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

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12 December 2020

10.1523/JNEUROSCI.22-22-09785.2002

Identifiers

DOI

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14 December 2019

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14 December 2019

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