A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice. (Q48435698)

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scientific article published on 8 November 2016

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English	A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice.	scientific article published on 8 November 2016

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scholarly article

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice. (English)

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

amyotrophic lateral sclerosis

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based on heuristic

inferred from title

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Moussa B. H. Youdim

4

object named as

Moussa B H Youdim

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

Sagit Golko-Perez

1

object named as

Sagit Golko-Perez

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

5

object named as

Orly Weinreb

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

author name string

Tamar Amit

2

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

Orit Bar-Am

3

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

publication date

8 November 2016

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

Neurotoxicity Research

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

31

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http://europepmc.org/abstract/MED/27826939

2

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Europe PubMed Central

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http://europepmc.org/abstract/MED/27826939

230-244

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

https://scigraph.springernature.com/pub.10.1007/s12640-016-9677-6

0 references

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2.

1 reference

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Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.

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Molecular signatures of amyotrophic lateral sclerosis disease progression in hind and forelimb muscles of an SOD1(G93A) mouse model

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Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

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Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model.

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Intraspinal implantation of hNT neurons into SOD1 mice with apparent motor deficit.

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Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis

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Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation

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Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients.

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Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study

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Low intensity areas observed on T2-weighted magnetic resonance imaging of the cerebral cortex in various neurological diseases.

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Compartmental microfluidic system for studying muscle-neuron communication and neuromuscular junction maintenance.

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Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.

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Role of PGC-1α signaling in skeletal muscle health and disease

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Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study

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Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis

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Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice.

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Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

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Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.

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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

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Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

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Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model

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The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage

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Moving toward a predictive and personalized clinical approach in amyotrophic lateral sclerosis: novel developments and future directions in diagnosis, genetics, pathogenesis and therapies

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Dysregulation of iron metabolism in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

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Amyotrophic lateral sclerosis and skeletal muscle: an update.

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Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy.

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Frontotemporal dementia-amyotrophic lateral sclerosis complex is simulated by neurodegeneration with brain iron accumulation.

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Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes

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Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis

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Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

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Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27826939

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Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron disease

1 reference

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1 reference

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1 reference

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A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

1 reference

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1 reference

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Synthesis and evaluation of peptidic metal chelators for neuroprotection in neurodegenerative diseases

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Identifiers

10.1007/S12640-016-9677-6

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27826939

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