Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. (Q48198168)

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English	Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.	scientific article

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8 December 2019

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice (English)

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8 December 2019

Alzheimer's disease

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8 December 2019

Catriona A. McLean

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8 December 2019

Christian Czech

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8 December 2019

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Q X Li

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8 December 2019

C Maynard

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8 December 2019

R A Cherny

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8 December 2019

T Lynch

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J G Culvenor

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8 December 2019

J Trevaskis

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J E Tanner

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K A Bailey

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8 December 2019

K Beyreuther

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C L Masters

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1 June 1999

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8 December 2019

Journal of Neurochemistry

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8 December 2019

2479-2487

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8 December 2019

6

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8 December 2019

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate

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Generation of beta A4 from the amyloid protein precursor and fragments thereof

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Site-directed mutations in the VDJ junctional region of a T cell receptor beta chain cause changes in antigenic peptide recognition

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

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Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

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Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid precursor protein

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment

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Characterization of Alzheimer amyloid precursor protein transcripts in platelets and megakarocytes

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.

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Amyloid, the presenilins and Alzheimer's disease

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Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

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Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins.

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain.

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

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Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

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Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.

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Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

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Transgenic mice expressing APP-C100 in the brain.

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Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

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Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

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21 January 2018

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

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Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein

1 reference

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

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Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

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