Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds. (Q48141107)

9 February 2018

5 references

19 September 2019

2 October 2019

20 January 2021

26 January 2021

22 August 2022

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds. (English)

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9 February 2018

biomedical investigative technique

main subject

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19 September 2019

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2 October 2019

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20 January 2021

neuroprotective agent

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26 January 2021

Leonardo Pisani

3

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Marco Catto

object named as

Marco Catto

4

0 references

Angelo Carotti

5

object named as

Angelo Carotti

1 reference

9 February 2018

author name string

Angela Stefanachi

1

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9 February 2018

Francesco Leonetti

2

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9 February 2018

language of work or name

English

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publication date

27 January 2018

6 references

9 February 2018

19 September 2019

2 October 2019

20 January 2021

26 January 2021

22 August 2022

5 references

9 February 2018

19 September 2019

2 October 2019

20 January 2021

26 January 2021

23

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9 February 2018

issue

2

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9 February 2018

Creative Commons Attribution

copyright license

5 references

19 September 2019

2 October 2019

20 January 2021

26 January 2021

22 August 2022

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Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors

1 reference

12 December 2020

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription

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12 December 2020

Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates

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12 December 2020

Metabolism and toxicity of coumarin on cultured human, rat, mouse and rabbit hepatocytes

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12 December 2020

Coumarin-induced hepatotoxicity

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12 December 2020

Evaluation of the developmental toxicities of coumarin, 4-hydroxycoumarin, and 7-hydroxycoumarin using FETAX.

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12 December 2020

Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment

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12 December 2020

CYP2A6: a human coumarin 7-hydroxylase

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12 December 2020

Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates

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12 December 2020

In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity

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12 December 2020

Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs

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12 December 2020

Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates

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12 December 2020

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.

1 reference

12 December 2020

The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans

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12 December 2020

Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies

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12 December 2020

3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy

1 reference

12 December 2020

The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

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12 December 2020

Announcing the worldwide Protein Data Bank

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12 December 2020

Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins

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12 December 2020

Coumarins in polymers: from light harvesting to photo-cross-linkable tissue scaffolds

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12 December 2020

Structure and mechanism of monoamine oxidase

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12 December 2020

Biochemical and biological characterization of a novel anti-aromatase coumarin derivative

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12 December 2020

A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes

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12 December 2020

Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity

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12 December 2020

Coumarin and isocoumarin as serine protease inhibitors.

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12 December 2020

Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer

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12 December 2020

Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.

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12 December 2020

Synthetic and natural coumarins as cytotoxic agents

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12 December 2020

Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity.

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12 December 2020

Structural basis for an unexpected mode of SERM-mediated ER antagonism

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12 December 2020

Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening

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12 December 2020

Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance

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12 December 2020

Synthesis and antiinflammatory activity of coumarin derivatives

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12 December 2020

Three-dimensional model of the human aromatase enzyme and density functional parameterization of the iron-containing protoporphyrin IX for a molecular dynamics study of heme-cysteinato cytochromes.

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12 December 2020

A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.

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12 December 2020

Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches

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12 December 2020

Impact of species-dependent differences on screening, design, and development of MAO B inhibitors

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12 December 2020

Lipophilicity plays a major role in modulating the inhibition of monoamine oxidase B by 7-substituted coumarins.

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12 December 2020

CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?

1 reference

12 December 2020

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase

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12 December 2020

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs

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12 December 2020

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

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12 December 2020

Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana

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12 December 2020

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors

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12 December 2020

Synthesis and biological evaluation of polymethoxylated 4-heteroarylcoumarins as tubulin assembly inhibitor

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12 December 2020

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

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12 December 2020

Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs

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12 December 2020

Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates

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12 December 2020

Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins

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12 December 2020

Synthesis and biological evaluation of new geiparvarin derivatives

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12 December 2020

Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, R

1 reference

12 December 2020

Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

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12 December 2020

Toxicology and risk assessment of coumarin: focus on human data

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12 December 2020

Phenylpropanoid biosynthesis

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12 December 2020

Fulvestrant - a novel endocrine therapy for breast cancer.

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12 December 2020

Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives.

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12 December 2020

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors

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12 December 2020

Toxicity of coumarin and various methyl derivatives in cultures of rat hepatocytes and V79 cells

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12 December 2020

Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases.

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12 December 2020

Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents

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12 December 2020

MAO inhibitors: risks, benefits, and lore

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12 December 2020

Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase

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12 December 2020

In silico identification of viper phospholipaseA2 inhibitors: validation by in vitro, in vivo studies

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12 December 2020

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

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12 December 2020

Developmental effects of coumarin and the anticoagulant coumarin derivative warfarin on zebrafish (Danio rerio) embryos.

1 reference

12 December 2020

Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases

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12 December 2020

Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.

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12 December 2020

Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors

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12 December 2020

Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents

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12 December 2020

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease

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12 December 2020

Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells.

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12 December 2020

Strategies of multi-objective optimization in drug discovery and development

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12 December 2020

CYP2A6: genetics, structure, regulation, and function

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12 December 2020

Neoflavonoids and tetrahydroquinolones as possible cancer chemopreventive agents.

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12 December 2020

The antioxidant activity of coumarins and flavonoids

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12 December 2020

Natural product coumarins that inhibit human carbonic anhydrases

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12 December 2020

Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors

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12 December 2020

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase

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12 December 2020

Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders

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12 December 2020

Human cytochromes P450 in health and disease

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12 December 2020

Computational methods for the design of potent aromatase inhibitors

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12 December 2020

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

1 reference

12 December 2020

Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study

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12 December 2020

A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.

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12 December 2020

Antithrombotic activity of a newly synthesized coumarin derivative 3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-N-{2-[3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-propionylamino]-ethyl}-propionamide

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12 December 2020

Combinatorial biosynthesis of plant-specific coumarins in bacteria

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12 December 2020

Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease

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12 December 2020

Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA.

1 reference

12 December 2020

Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.

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12 December 2020

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.

1 reference

12 December 2020

Heme enzyme structure and function

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12 December 2020

Multifunctional compounds: smart molecules for multifactorial diseases

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12 December 2020

Insight into the Functional and Structural Properties of 3-Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition

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12 December 2020

Monoamine Oxidase (MAO) Inhibitory Activity: 3-Phenylcoumarins versus 4-Hydroxy-3-phenylcoumarins

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12 December 2020

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases

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12 December 2020

Coumarin hybrids as novel therapeutic agents

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12 December 2020

Two-year, randomized, controlled study of safinamide as add-on to levodopa in mid to late Parkinson's disease.

1 reference

12 December 2020

Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase

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12 December 2020

Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors

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12 December 2020

Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase

1 reference

12 December 2020

Toward the first class of suicide inhibitors of kallikreins involved in skin diseases

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12 December 2020

Silver-mediated radical cyclization of alkynoates and α-keto acids leading to coumarins via cascade double C-C bond formation.

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12 December 2020

Cardiovascular effects of coumarins besides their antioxidant activity

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12 December 2020

Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

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12 December 2020

Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.

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12 December 2020

Visible-light-mediated radical aryldifluoroacetylation of alkynes with ethyl bromodifluoroacetate for the synthesis of 3-difluoroacetylated coumarins.

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12 December 2020

Biological synthesis of coumarins in Escherichia coli

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12 December 2020

Microwave-Assisted Copper-Catalyzed Four-Component Tandem Synthesis of 3-N-Sulfonylamidine Coumarins

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12 December 2020

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

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12 December 2020

Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents

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12 December 2020

Coumarins as Potential Inhibitors of DNA Polymerases and Reverse Transcriptases. Searching New Antiretroviral and Antitumoral Drugs

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12 December 2020

Coumarins as anticancer agents: a review on synthetic strategies, mechanism of action and SAR studies

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12 December 2020

3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

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12 December 2020

Relationship between coumarin-induced hepatocellular toxicity and mitochondrial function in rats.

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12 December 2020

Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease

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12 December 2020

Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif.

1 reference

12 December 2020

Coumarins as cholinesterase inhibitors: A review

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12 December 2020

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.

1 reference

12 December 2020

Antioxidant Activities of 4-Methylumbelliferone Derivatives

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12 December 2020

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

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12 December 2020

Fungi as a source of natural coumarins production

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12 December 2020

Visible-Light-Promoted Dual C-C Bond Formations of Alkynoates via a Domino Radical Addition/Cyclization Reaction: A Synthesis of Coumarins.

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12 December 2020

Therapeutic potential of coumarins as antiviral agents

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12 December 2020

Rational Design of Coumarin Derivatives as CK2 Inhibitors by Improving the Interaction with the Hinge Region

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12 December 2020

Natural and Synthetic Coumarins with Effects on Inflammation

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12 December 2020

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.

1 reference

12 December 2020

A Regioselective Metal-Free Construction of 3-Aroyl Coumarins by Csp2-H Functionalization

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12 December 2020

Computational Multitarget Drug Design.

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12 December 2020

A rational approach to elucidate human monoamine oxidase molecular selectivity

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12 December 2020

Coumarins scaffolds as COX inhibitors

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12 December 2020

Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure-Activity Relationships Predictive Models

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12 December 2020

Evaluation of synthesized coumarin derivatives on aromatase inhibitory activity.

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12 December 2020

Structures of antimutagenic constituents in the peels of Citrus limon.

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12 December 2020

Coumarin derivatives: an updated patent review (2015-2016).

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12 December 2020

Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.

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12 December 2020

Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease

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12 December 2020

Ultrasonic accelerated Knoevenagel condensation by magnetically recoverable MgFe2O4 nanocatalyst: A rapid and green synthesis of coumarins under solvent-free conditions.

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12 December 2020

10.3390/MOLECULES23020250

Identifiers

DOI

1 reference

9 February 2018

PMC publication ID

6017103

0 references

1 reference

9 February 2018