A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry. (Q48119987)

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27 February 2020

title

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry (English)

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1

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author name string

Upendra P Dahal

2

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27 February 2020

Andrew J Bessire

3

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27 February 2020

Richard P Schneider

4

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27 February 2020

Kieran F Geoghegan

5

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27 February 2020

Alfin D N Vaz

6

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publication date

1 November 2015

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Rapid Communications in Mass Spectrometry

27 February 2020

published in

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volume

29

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issue

22

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page(s)

2175-2183

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describes a project that uses

27 February 2020

1 reference

Enzymatic activation of chemicals to toxic metabolites.

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Protein targets of xenobiotic reactive intermediates

21 January 2018

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Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.

21 January 2018

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Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction

21 January 2018

1 reference

Benchmarking in vitro covalent binding burden as a tool to assess potential toxicity caused by nonspecific covalent binding of covalent drugs.

21 January 2018

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Monitoring drug-protein interaction

21 January 2018

1 reference

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

21 January 2018

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Development of clickable active site-directed photoaffinity probes for γ-secretase

21 January 2018

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An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease

21 January 2018

1 reference

Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.

21 January 2018

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Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

21 January 2018

1 reference

Profiling enzyme activities in vivo using click chemistry methods

21 January 2018

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Initiation of translation at an upstream non-AUG codon accounting for N-terminally extended minor forms of recombinant proteins expressed in insect cells

21 January 2018

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Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase I pharmacokinetic and food effect study

21 January 2018

1 reference

Pharmacokinetics of afatinib in subjects with mild or moderate hepatic impairment

21 January 2018

1 reference

The role of extrahepatic metabolism in the pharmacokinetics of the targeted covalent inhibitors afatinib, ibrutinib, and neratinib

21 January 2018

1 reference

Determination of human serum alpha1-acid glycoprotein and albumin binding of various marketed and preclinical kinase inhibitors.

21 January 2018

1 reference

Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients

21 January 2018

1 reference

Identification of liver protein targets modified by tienilic acid metabolites using a two-dimensional Western blot-mass spectrometry approach

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/RCM.7375

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27 February 2020

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