CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy. (Q48112768)

http://europepmc.org/abstract/PMC/5676903

2 July 2018

title

CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy. (English)

1 reference

http://europepmc.org/abstract/PMC/5676903

2 July 2018

0 references

0 references

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29078326%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Michael R Green

15

1 reference

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6 June 2020

Sebastian Matuszewski

4

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6 June 2020

Jianhong Ou

6

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6 June 2020

Richard D Press

8

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6 June 2020

Susan Branford

11

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6 June 2020

author name string

Leyuan Ma

1

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6 June 2020

Jeffrey I Boucher

2

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6 June 2020

Janet Paulsen

3

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6 June 2020

Christopher A Eide

5

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6 June 2020

Garrett Eickelberg

7

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6 June 2020

Lihua Julie Zhu

9

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6 June 2020

Brian J Druker

10

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6 June 2020

Scot A Wolfe

12

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6 June 2020

Celia A Schiffer

14

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6 June 2020

Daniel N Bolon

16

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6 June 2020

language of work or name

English

0 references

publication date

16 October 2017

1 reference

http://europepmc.org/abstract/PMC/5676903

2 July 2018

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

Proceedings of the National Academy of Sciences of the United States of America

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6 June 2020

volume

114

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6 June 2020

issue

44

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6 June 2020

page(s)

11751-11756

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29078326%20AND%20SRC:MED&resulttype=core&format=json

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.

6 June 2020

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1 reference

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3 July 2018

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Saturation editing of genomic regions by multiplex homology-directed repair

3 July 2018

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BCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Ph chromosome-positive leukemia

3 July 2018

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Deep mutational scanning: a new style of protein science

3 July 2018

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Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain

3 July 2018

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Cancer drug resistance: an evolving paradigm

3 July 2018

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Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

3 July 2018

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3 July 2018

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A biophysical protein folding model accounts for most mutational fitness effects in viruses

3 July 2018

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BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet

3 July 2018

1 reference

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Experimental illumination of a fitness landscape

3 July 2018

1 reference

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AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

3 July 2018

1 reference

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Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for Molecular Pathology.

3 July 2018

1 reference

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Activation of tyrosine kinases by mutation of the gatekeeper threonine

3 July 2018

1 reference

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Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study

3 July 2018

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A decade of fragment-based drug design: strategic advances and lessons learned

3 July 2018

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The FoldX web server: an online force field

3 July 2018

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Patterns of nucleotide substitution, insertion and deletion in the human genome inferred from pseudogenes

3 July 2018

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

3 July 2018

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Mechanisms of cancer drug resistance

3 July 2018

1 reference

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

3 July 2018

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Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

3 July 2018

1 reference

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Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

3 July 2018

1 reference

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Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?

14 August 2018

1 reference

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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

14 August 2018

1 reference

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14 August 2018

Identifiers

DOI

10.1073/PNAS.1708268114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29078326%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29078326%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference