Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT. (Q48091849)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29259101%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

title

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT (English)

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7 April 2020

1

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7 April 2020

Laura Ghisolfi

2

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7 April 2020

Renee C Geck

3

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7 April 2020

Alex Toker

5

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7 April 2020

author name string

John M Asara

4

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7 April 2020

publication date

19 December 2017

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7 April 2020

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7 April 2020

volume

10

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7 April 2020

issue

510

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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

7 April 2020

cites work

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15 July 2018

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15 July 2018

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Transsulfuration Is a Significant Source of Sulfur for Glutathione Production in Human Mammary Epithelial Cells

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15 July 2018

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Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation

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A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

15 July 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

15 July 2018

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PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

15 July 2018

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Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro

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The treatment of hyperhomocysteinemia

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

15 July 2018

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

15 July 2018

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15 July 2018

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15 July 2018

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15 July 2018

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15 July 2018

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15 July 2018

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Contribution of 4-methylthio-2-oxobutanoate and its transaminase to the growth of methionine-dependent cells in culture. Effect of transaminase inhibitors

15 July 2018

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Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo

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Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial.

15 July 2018

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The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture

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Reversion to methionine independence by malignant rat and SV40-transformed human fibroblasts

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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

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14 August 2018

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14 August 2018

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14 August 2018

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14 August 2018

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Methionine depletion enhances the antitumoral efficacy of cytotoxic agents in drug-resistant human tumor xenografts.

14 August 2018

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Effect of long-term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice.

14 August 2018

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Methylthioadenosine phosphorylase deficiency in human leukemias and solid tumors

14 August 2018

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12 December 2020

Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect

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12 December 2020

Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet

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12 December 2020

N5-methyltetrahydrofolate: Homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells

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12 December 2020

Effect of essential amino acid restriction on the growth of female C57BL mice and their implanted BW10232 adenocarcinomas

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12 December 2020

The metabolic defect of methionine dependence occurs frequently in human tumor cell lines

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12 December 2020

Human tumors are methionine dependent in vivo

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12 December 2020

Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture

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12 December 2020

Molecular mechanisms of cell cycle block by methionine restriction in human prostate cancer cells

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12 December 2020

10.1126/SCISIGNAL.AAO6604

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29259101%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29259101%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

PubMed publication ID

29259101

1 reference