Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. (Q47936492)

6 February 2018

title

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. (English)

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6 February 2018

1 reference

Thomas Calzascia

2

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Marc Pellegrini

Marc Pellegrini

1

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Pamela Ohashi

Pamela S Ohashi

14

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Tak Wah Mak

15

Tak W Mak

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6 February 2018

Michel Morre

10

Michel Morre

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6 February 2018

Brigitte Assouline

11

Brigitte Assouline

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6 February 2018

Salim Dhanji

7

Salim Dhanji

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6 February 2018

Arda Shahinian

4

Arda Shahinian

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6 February 2018

Alisha R Elford

3

Alisha R Elford

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6 February 2018

Dilan Dissanayake

6

Dilan Dissanayake

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6 February 2018

author name string

Amy E Lin

5

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6 February 2018

Linh T Nguyen

8

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6 February 2018

Matthew A Gronski

9

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6 February 2018

Katharina Lahl

12

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6 February 2018

Tim Sparwasser

13

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6 February 2018

language of work or name

English

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publication date

26 April 2009

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6 February 2018

published in

Nature Medicine

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6 February 2018

volume

15

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6 February 2018

issue

5

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6 February 2018

page(s)

528-536

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6 February 2018

https://scigraph.springernature.com/pub.10.1038/nm.1953

exact match

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cites work

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IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis

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Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo

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Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice

21 January 2018

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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

21 January 2018

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12 December 2020

Intratumoral administration of adenoviral interleukin 7 gene-modified dendritic cells augments specific antitumor immunity and achieves tumor eradication

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

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Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

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Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

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New battlefields for costimulation

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Ablation of Cbl-b provides protection against transplanted and spontaneous tumors

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Interleukin 7 promotes long-term in vitro growth of antitumor cytotoxic T lymphocytes with immunotherapeutic efficacy in vivo

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TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice

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Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors.

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Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

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TCR affinity and negative regulation limit autoimmunity

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Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

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Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells

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Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation

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Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

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Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis

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B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells

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Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

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Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

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The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells

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12 December 2020

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

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12 December 2020

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

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12 December 2020

Cbl-b regulates the CD28 dependence of T-cell activation.

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12 December 2020

Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines

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12 December 2020

Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice

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12 December 2020

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

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12 December 2020

A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

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12 December 2020

Identifiers

DOI

10.1038/NM.1953

1 reference

6 February 2018

PubMed ID

19396174

1 reference

6 February 2018