Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease. (Q47884196)

6 February 2018

title

Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease. (English)

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6 February 2018

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M Hasan Mohajeri

1

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6 February 2018

Katrin Kuehnle

2

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6 February 2018

Hong Li

3

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6 February 2018

Raphael Poirier

4

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6 February 2018

Jay Tracy

5

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6 February 2018

Roger M Nitsch

6

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6 February 2018

language of work or name

English

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publication date

1 March 2004

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6 February 2018

published in

FEBS Letters

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6 February 2018

volume

562

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6 February 2018

issue

1-3

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6 February 2018

page(s)

16-21

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6 February 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo.

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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

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A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11)

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

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10.1016/S0014-5793(04)00169-3

7 January 2021

Identifiers

DOI

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6 February 2018

PubMed ID

15043995

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6 February 2018