Protein prenylation: from discovery to prospects for cancer treatment. (Q47829646)

6 February 2018

review article

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title

Protein prenylation: from discovery to prospects for cancer treatment. (English)

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6 February 2018

author name string

Gelb MH

series ordinal

1

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6 February 2018

Scholten JD

series ordinal

2

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6 February 2018

Sebolt-Leopold JS

series ordinal

3

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6 February 2018

publication date

1 February 1998

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6 February 2018

Current Opinion in Chemical Biology

published in

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6 February 2018

volume

2

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6 February 2018

issue

1

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6 February 2018

page(s)

40-48

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6 February 2018

Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides

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Isoprenylated proteins in cultured cells: subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

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Identification of geranylgeranyl-modified proteins in HeLa cells

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Prenylated proteins: the structure of the isoprenoid group

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p21ras is modified by a farnesyl isoprenoid

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Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein

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All ras proteins are polyisoprenylated but only some are palmitoylated

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Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini

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G protein gamma subunits contain a 20-carbon isoprenoid

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7 January 2021

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester

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7 January 2021

Protein prenylation: molecular mechanisms and functional consequences

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7 January 2021

Prenylation of proteins in Trypanosoma brucei

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7 January 2021

A microsomal endoprotease that specifically cleaves isoprenylated peptides

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7 January 2021

A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide

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Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

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Farnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometry

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Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro

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Novel methyltransferase activity modifying the carboxy terminal bis(geranylgeranyl)-Cys-Ala-Cys structure of small GTP-binding proteins

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Dynamic protein acylation and the regulation of localization and function of signal-transducing proteins

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Targeting lamin proteins to the nuclear envelope: the role of CaaX box modifications.

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7 January 2021

Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes.

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7 January 2021

Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange

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Replacement of the H-Ras farnesyl group by lipid analogues: implications for downstream processing and effector activation in Xenopus oocytes.

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The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase.

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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

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Farnesylated γ-subunit of photoreceptor G protein indispensable for GTP-binding

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A specific beta gamma-subunit of transducin stimulates ADP-ribosylation of the alpha-subunit by pertussis toxin

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Prenyl modification of guanine nucleotide regulatory protein gamma 2 subunits is not required for interaction with the transducin alpha subunit or rhodopsin

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Carboxyl methylation and farnesylation of transducin gamma-subunit synergistically enhance its coupling with metarhodopsin II.

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7 January 2021

Roles of lipid modifications of transducin subunits in their GDP-dependent association and membrane binding

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7 January 2021

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

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7 January 2021

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

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7 January 2021

Protein prenyltransferases

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A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

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Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid

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7 January 2021

Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

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Steady-state kinetic mechanism of Ras farnesyl:protein transferase

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Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling

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Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

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7 January 2021

Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation

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Substrate binding is required for release of product from mammalian protein farnesyltransferase

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Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate

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7 January 2021

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

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7 January 2021

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

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7 January 2021

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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7 January 2021

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

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7 January 2021

Photoreactive analogues of prenyl diphosphates as inhibitors and probes of human protein farnesyltransferase and geranylgeranyltransferase type I

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7 January 2021

Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme.

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Yeast protein farnesyltransferase. Site-directed mutagenesis of conserved residues in the beta-subunit

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Ras farnesyltransferase: a new therapeutic target

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Farnesyltransferase as a target for anticancer drug design

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Synergy between anions and farnesyldiphosphate competitive inhibitors of farnesyl:protein transferase

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Discovery of novel nonpeptide tricyclic inhibitors of Ras farnesyl protein transferase

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C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice

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7 January 2021

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

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7 January 2021

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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TC21 causes transformation by Raf-independent signaling pathways

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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7 January 2021

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Identifiers

DOI

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6 February 2018

PubMed ID

9667914

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6 February 2018