The ligand binding site of NPY at the rat Y1 receptor investigated by site-directed mutagenesis and molecular modeling (Q47683924)

4 February 2018

title

The ligand binding site of NPY at the rat Y1 receptor investigated by site-directed mutagenesis and molecular modeling (English)

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author name string

Robin-Jagerschmidt C

1

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Bihoreau C

3

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Hendricksen L

4

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Calvet A

5

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Dahl SG

6

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Bénicourt C

7

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publication date

1 April 1998

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Molecular and Cellular Endocrinology

published in

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4 February 2018

volume

139

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issue

1-2

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page(s)

187-198

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4 February 2018

describes a project that uses

site-directed mutagenesis

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The probable arrangement of the helices in G protein-coupled receptors.

inferred from title

cites work

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Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY

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Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

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Empirical Predictions of Protein Conformation

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Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport

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Functional characterization of receptors with affinity for PYY, NPY, [Leu31,Pro34]NPY and PP in a human colonic epithelial cell line.

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Model systems for the study of seven-transmembrane-segment receptors

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Three-dimensional structure of membrane and surface proteins

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Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family

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The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides

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[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist

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Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

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Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models

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Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

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Cloned human neuropeptide Y receptor couples to two different second messenger systems

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Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor

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High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment.

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Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY

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Solubilization of the Neuropeptide Y Receptor from Rat Brain Membranes

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A practical computer-based approach to the analysis of radioligand binding experiments

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7 January 2021

Sequence alignment of the G-protein coupled receptor superfamily

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7 January 2021

Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor

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7 January 2021

Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding

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In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

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Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides.

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Cloning and expression of a novel neuropeptide Y receptor

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7 January 2021

Changes in binding activity of luteinizing hormone receptors by site directed mutagenesis of potential glycosylation sites

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7 January 2021

10.1016/S0303-7207(98)00060-4

Identifiers

DOI

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4 February 2018

PubMed ID

9705087

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4 February 2018