Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity. (Q47682436)

4 February 2018

title

Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity. (English)

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4 February 2018

author name string

Winkler DG

1

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4 February 2018

Cutler RE Jr

2

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4 February 2018

Drugan JK

3

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4 February 2018

Campbell S

4

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4 February 2018

Morrison DK

5

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4 February 2018

Cooper JA

6

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4 February 2018

language of work or name

English

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publication date

1 August 1998

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4 February 2018

Journal of Biological Chemistry

published in

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4 February 2018

volume

273

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4 February 2018

page(s)

21578-21584

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4 February 2018

issue

34

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4 February 2018

Identification and characterization of mutations in Ha-Ras that selectively decrease binding to cRaf-1.

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Raf meets Ras: completing the framework of a signal transduction pathway

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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

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The complexity of Raf-1 regulation

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MAP kinase pathways. Straight and narrow or tortuous and intersecting?

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Mutational activation of c-raf-1 and definition of the minimal transforming sequence

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Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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Association of pRas and pRaf-1 in a complex correlates with activation of a signal transduction pathway

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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Activation of Raf as a result of recruitment to the plasma membrane

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Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

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Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

21 January 2018

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An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

21 January 2018

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Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

21 January 2018

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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

21 January 2018

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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

21 January 2018

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

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Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

21 January 2018

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Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

21 January 2018

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The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

21 January 2018

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Two distinct Raf domains mediate interaction with Ras

21 January 2018

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14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

21 January 2018

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Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila

21 January 2018

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14-3-3: modulators of signaling proteins?

21 January 2018

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Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases

21 January 2018

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Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

21 January 2018

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Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

21 January 2018

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Activation of Raf-1 by 14-3-3 proteins

21 January 2018

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14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

21 January 2018

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

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Ras-Raf interaction: two-hybrid analysis

21 January 2018

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Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription

21 January 2018

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Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate

21 January 2018

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Biological assays for Ras transformation

21 January 2018

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Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

21 January 2018

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Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

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Multiple regulatory domains on the Byr2 protein kinase

21 January 2018

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Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger

21 January 2018

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Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

21 January 2018

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Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.34.21578

1 reference

4 February 2018

PubMed ID

9705288

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4 February 2018