The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway. (Q47675041)

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scientific article published in February 2015

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English	The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway.	scientific article published in February 2015

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1 March 2020

The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway (English)

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1 March 2020

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Joanna Pucilowska

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1 March 2020

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Joseph Vithayathil

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Emmanuel J Tavares

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Caitlin Kelly

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J Colleen Karlo

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Gary E Landreth

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1 February 2015

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1 March 2020

Journal of Neuroscience

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3190-3200

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1 March 2020

CDK inhibitors: positive and negative regulators of G1-phase progression

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12 December 2020

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Radial glial identity is promoted by Notch1 signaling in the murine forebrain

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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage

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Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

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Neurons derived from radial glial cells establish radial units in neocortex

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Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression

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Human brain malformations and their lessons for neuronal migration

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Molecular psychology: roles for the ERK MAP kinase cascade in memory

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Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

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An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis

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12 December 2020

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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

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Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis

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12 December 2020

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The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling

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12 December 2020

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Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons.

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12 December 2020

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Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex

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12 December 2020

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ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis.

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12 December 2020

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Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone

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12 December 2020

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Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets

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12 December 2020

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The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex

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12 December 2020

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Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion

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Deregulated Ras signaling in developmental disorders: new tricks for an old dog.

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12 December 2020

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Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity.

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12 December 2020

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Cell-cycle control and cortical development

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12 December 2020

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The new neurobiology of autism: cortex, connectivity, and neuronal organization

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12 December 2020

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Mapping Early Brain Development in Autism

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https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

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Recurrent 16p11.2 microdeletions in autism

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https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

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Association between microdeletion and microduplication at 16p11.2 and autism

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https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

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Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.

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12 December 2020

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Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

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MAP'ing CNS development and cognition: an ERKsome process

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12 December 2020

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Cell cycle dependence of laminar determination in developing neocortex

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12 December 2020

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The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

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12 December 2020

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Total brain volume and corpus callosum size in medication-naïve adolescents and young adults with autism spectrum disorder

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https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

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Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex

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12 December 2020

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Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations

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12 December 2020

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Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors.

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12 December 2020

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Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder

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12 December 2020

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Microduplications of 16p11.2 are associated with schizophrenia

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12 December 2020

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Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times

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12 December 2020

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MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway.

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12 December 2020

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Lentiviral vectors to study the differential function of ERK1 and ERK2 MAP kinases

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12 December 2020

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ERK1 and ERK2 are required for radial glial maintenance and cortical lamination.

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12 December 2020

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Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms

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https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

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Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice

1 reference

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12 December 2020

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Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex

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12 December 2020

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Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

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Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders

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12 December 2020

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ERK2 contributes to the control of social behaviors in mice.

1 reference

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12 December 2020

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Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism

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12 December 2020

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ERK1/2 MAP kinases: structure, function, and regulation

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12 December 2020

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Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

based on heuristic

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Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders

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12 December 2020

based on heuristic

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The RASopathies

1 reference

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12 December 2020

based on heuristic

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Convergence of genes and cellular pathways dysregulated in autism spectrum disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

based on heuristic

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Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/25698753

12 December 2020

based on heuristic

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Opposing brain differences in 16p11.2 deletion and duplication carriers

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12 December 2020

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The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

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12 December 2020

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Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint

1 reference

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12 December 2020

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Identifiers

10.1523/JNEUROSCI.4864-13.2015

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1 March 2020

1 reference

Europe PubMed Central

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1 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25698753%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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