Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients. (Q47602482)

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English	Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients.	scientific article

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scholarly article

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2 April 2020

Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients (English)

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pharmacokinetics

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based on heuristic

inferred from title

pharmacodynamics

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based on heuristic

inferred from title

1

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author name string

Kristina M Brooks

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Cheng Cai Tang

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Paul Wakim

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Mary Blake

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Stephen R Brooks

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Gina A Montealegre Sanchez

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Adriana A de Jesus

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Yan Huang

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Wanxia Li Tsai

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Massimo Gadina

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Apurva Prakash

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Jonathan Marcus Janes

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Xin Zhang

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William L Macias

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Parag Kumar

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Raphaela Goldbach-Mansky

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8 December 2017

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Clinical Pharmacology & Therapeutics

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104

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364-373

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2

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2 April 2020

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

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Insights from Mendelian Interferonopathies: Comparison of CANDLE, SAVI with AGS, Monogenic Lupus.

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Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

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The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers.

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Identifiers

10.1002/CPT.936

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2 April 2020

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2 April 2020

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