Gain-of-function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies. (Q47428832)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29113963%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies (English)

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9 April 2020

5

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9 April 2020

Peng Zhang

12

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9 April 2020

J William Harbour

18

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author name string

Hui Yang

1

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9 April 2020

Stefan Kurtenbach

2

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9 April 2020

Ying Guo

3

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9 April 2020

Ines Lohse

4

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9 April 2020

Jianping Li

6

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9 April 2020

Zhaomin Li

7

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9 April 2020

Hassan Al-Ali

8

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9 April 2020

Lingxiao Li

9

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9 April 2020

Zizhen Chen

10

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9 April 2020

Matthew G Field

11

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9 April 2020

Shi Chen

13

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9 April 2020

Shohei Yamamoto

14

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9 April 2020

Zhuo Li

15

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9 April 2020

Yuan Zhou

16

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9 April 2020

Stephen D Nimer

17

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9 April 2020

Claes Wahlestedt

19

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9 April 2020

Mingjiang Xu

20

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Feng-Chun Yang

21

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9 April 2020

language of work or name

English

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publication date

7 November 2017

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9 April 2020

number of pages

14

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inferred from page(s)

published in

Blood

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9 April 2020

volume

131

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9 April 2020

page(s)

328-341

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issue

3

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ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

9 April 2020

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1 reference

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BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

29 September 2018

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Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.

29 September 2018

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Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

29 September 2018

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Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex

29 September 2018

1 reference

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The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia.

29 September 2018

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Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation

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Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome.

29 September 2018

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Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

29 September 2018

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Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

29 September 2018

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Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

29 September 2018

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

29 September 2018

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Functional and cancer genomics of ASXL family members

29 September 2018

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

29 September 2018

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29 September 2018

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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

29 September 2018

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Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

29 September 2018

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Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms.

29 September 2018

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Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

29 September 2018

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CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.

29 September 2018

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29 September 2018

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Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.

29 September 2018

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Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations

29 September 2018

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ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1

29 September 2018

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Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.

29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor

29 September 2018

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29 September 2018

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A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11

29 September 2018

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Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment

29 September 2018

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Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines

29 September 2018

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ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia

29 September 2018

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12 December 2020

High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression

1 reference

12 December 2020

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

1 reference

12 December 2020

Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia

1 reference

12 December 2020

10.1182/BLOOD-2017-06-789669

Identifiers

DOI

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9 April 2020

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9 April 2020

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