HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded (Q47423769)

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scientific article published on 8 November 2017

Language	Label	Description	Also known as
English	HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded	scientific article published on 8 November 2017

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scholarly article

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Europe PubMed Central

10 July 2018

http://europepmc.org/abstract/PMC/5752949

HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded (English)

1 reference

Europe PubMed Central

10 July 2018

http://europepmc.org/abstract/PMC/5752949

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based on heuristic

inferred from title

14

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8 June 2020

2

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8 June 2020

author name string

Briana Quitadamo

1

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8 June 2020

Alexander Repik

3

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8 June 2020

Olivia O'Connell

4

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8 June 2020

Zhongming Mou

5

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8 June 2020

Matthew Koch

6

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8 June 2020

Mohan Somasundaran

7

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8 June 2020

Robin Brody

8

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8 June 2020

Katherine Luzuriaga

9

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8 June 2020

Aaron Wallace

10

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8 June 2020

Shixia Wang

11

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8 June 2020

Shan Lu

12

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8 June 2020

Sean McCauley

13

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8 June 2020

Maria Duenas-Decamp

15

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8 June 2020

Maria Paz Gonzalez-Perez

16

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8 June 2020

Paul R Clapham

17

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8 June 2020

language of work or name

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publication date

2 January 2018

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Europe PubMed Central

10 July 2018

http://europepmc.org/abstract/PMC/5752949

Journal of Virology

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8 June 2020

92

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8 June 2020

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29118121%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications

1 reference

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15 July 2018

Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations

1 reference

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15 July 2018

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

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15 July 2018

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

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15 July 2018

R5 Macrophage-Tropic HIV-1 in the Male Genital Tract

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Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

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Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection

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15 July 2018

HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages

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15 July 2018

HIV-1 gp120 dimers decrease the overall affinity of gp120 preparations for CD4-induced ligands

1 reference

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15 July 2018

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

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15 July 2018

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

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Unique features of HIV-1 spread through T cell virological synapses

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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

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15 July 2018

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

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15 July 2018

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

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15 July 2018

Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

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15 July 2018

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

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15 July 2018

Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism

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15 July 2018

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.

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15 July 2018

HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes

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HIV-1 replication in the central nervous system occurs in two distinct cell types.

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Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

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A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection

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Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

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HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12.

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In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1

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15 July 2018

Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes

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15 July 2018

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

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Mutations in envelope gp120 can impact proteolytic processing of the gp160 precursor and thereby affect neutralization sensitivity of human immunodeficiency virus type 1 pseudoviruses.

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Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail

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Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.

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The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.

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15 July 2018

Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.

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15 July 2018

Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enh

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15 July 2018

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15 July 2018

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15 July 2018

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Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.00841-17

1 reference

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8 June 2020

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8 June 2020

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8 June 2020

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