Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study (Q47374036)

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scientific article published on 18 November 2017

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English	Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study	scientific article published on 18 November 2017

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scholarly article

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Europe PubMed Central

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15 January 2018

http://europepmc.org/abstract/MED/29165638

Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study (English)

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Europe PubMed Central

PubMed publication ID

15 January 2018

http://europepmc.org/abstract/MED/29165638

hypermethylation

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based on heuristic

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Benedikt Brors

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Jürgen Debus

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Wolfgang Wick

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Martin Bendszus

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Martin Bendszus

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Felix Sahm

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Andreas von Deimling

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Andreas von Deimling

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David Capper

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Christel Herold-Mende

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Christel Herold-Mende

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Daniel Schrimpf

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Daniel Schrimpf

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Stefan M. Pfister

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Stefan M Pfister

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David T. W. Jones

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David T W Jones

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Antje Wick

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Elke Pfaff

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Tobias Kessler

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Gnana Prakash Balasubramanian

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Anne Berberich

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Andreas Unterberg

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Irini Schenkel

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Andreas Eisenmenger

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Susan Dettmer

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Michael Platten

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publication date

18 November 2017

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http://europepmc.org/abstract/MED/29165638

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

1 reference

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Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

1 reference

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A comprehensive analysis identifies BRAF hotspot mutations associated with gliomas with peculiar epithelial morphology.

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Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

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Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study

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Frequency of BRAF V600E mutations in 969 central nervous system neoplasms.

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Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).

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Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial.

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New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

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CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012.

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Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma

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26 August 2018

Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study

1 reference

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A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma

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Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial

1 reference

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MGMT testing--the challenges for biomarker-based glioma treatment

1 reference

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26 August 2018

ChAMP: 450k Chip Analysis Methylation Pipeline

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The somatic genomic landscape of glioblastoma

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Signatures of mutational processes in human cancer

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Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation

1 reference

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Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms

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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

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Transforming fusions of FGFR and TACC genes in human glioblastoma

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MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

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Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

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26 August 2018

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

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Identifiers

10.1093/NEUONC/NOX216

1 reference

Europe PubMed Central

PubMed publication ID

15 January 2018

http://europepmc.org/abstract/MED/29165638

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 January 2018

http://europepmc.org/abstract/MED/29165638

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