Serpin family A member 3 (Q4734974)

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mammalian protein found in Homo sapiens

growth-inhibiting protein 25
serpin A3
growth-inhibiting protein 24
alpha-1-antichymotrypsin
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
cell growth-inhibiting gene 24/25 protein
serine (or cysteine) proteinase inhibitor, clade A, member 3

Language	Label	Description	Also known as
English	Serpin family A member 3	mammalian protein found in Homo sapiens	growth-inhibiting protein 25 serpin A3 growth-inhibiting protein 24 alpha-1-antichymotrypsin SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 cell growth-inhibiting gene 24/25 protein serine (or cysteine) proteinase inhibitor, clade A, member 3

Statements

1 reference

13 November 2019

UniProt protein ID

Serpin superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01011

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01011

Serpin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serpin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

peptidase inhibitor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

determination method

1 reference

8 April 2019

The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

protein binding

determination method

4 references

8 April 2019

Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

Complex formation between human kallikrein 13 and serum protease inhibitors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

serine-type endopeptidase inhibitor activity

determination method

3 references

8 April 2019

Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

blood microparticle

determination method

1 reference

26 September 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

extracellular exosome

determination method

3 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

intracellular anatomical structure

determination method

1 reference

1 January 2018

Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

determination method

1 reference

8 April 2019

The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

platelet alpha granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

extracellular region

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

The human plasma proteome: a nonredundant list developed by combination of four separate sources

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

extracellular space

determination method

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

26 September 2017

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

26 September 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

secretory granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

azurophil granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

extracellular space

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

8 April 2019

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

blood microparticle

determination method

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

biological process

regulation of lipid metabolic process

determination method

1 reference

8 April 2019

Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

negative regulation of peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

inflammatory response

determination method

1 reference

8 April 2019

Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin, and their mixture

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

maintenance of gastrointestinal epithelium

determination method

1 reference

8 April 2019

Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

acute-phase response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

platelet degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

negative regulation of endopeptidase activity

determination method

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01011&geneProductId=UniProtKB:P01011

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

negative regulation of endopeptidase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01011

determination method

Gene Atlas image

PBB GE SERPINA3 202376 at fs.png
732 × 530; 11 KB

0 references

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01011

Serpin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01011

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000376793

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376793

ENSP00000376795

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376795

ENSP00000450540

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450540

ENSP00000451119

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451119

ENSP00000452246

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452246

ENSP00000452476

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452476

ENSP00000481617

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481617

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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