Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent (Q47268482)

13 January 2018

title

Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent (English)

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13 January 2018

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Hirokazu Tamamura

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Naoki Yamamoto

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object named as

Naoki Yamamoto

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author name string

Miho Fujisawa

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13 January 2018

Kenichi Hiramatsu

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Makiko Mizumoto

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Hideki Nakashima

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Akira Otaka

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Nobutaka Fujii

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language of work or name

English

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publication date

1 July 2004

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13 January 2018

published in

FEBS Letters

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volume

569

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page(s)

99-104

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issue

1-3

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Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium

cites work

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The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

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The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

21 January 2018

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21 January 2018

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A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

21 January 2018

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Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries

21 January 2018

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Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4

21 January 2018

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Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

21 January 2018

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Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists

21 January 2018

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Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives

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Non-steroidal anti-inflammatory drugs. Current status and rational therapeutic use.

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

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Involvement of chemokine receptors in breast cancer metastasis

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Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

21 January 2018

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Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin

21 January 2018

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Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists

21 January 2018

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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

21 January 2018

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21 January 2018

Identifiers

DOI

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13 January 2018

PubMed ID

15225616

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13 January 2018