UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition (Q47098704)

8 January 2018

title

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition (English)

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8 January 2018

Behnam Nabet

7

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Jonathan J Keats

object named as

Jonathan Keats

19

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author name string

Teresa Ezponda

1

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8 January 2018

Daphné Dupéré-Richer

2

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8 January 2018

Christine M Will

3

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8 January 2018

Eliza C Small

4

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8 January 2018

Nobish Varghese

5

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8 January 2018

Tej Patel

6

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8 January 2018

Relja Popovic

8

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8 January 2018

Jon Oyer

9

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8 January 2018

Marinka Bulic

10

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8 January 2018

Yupeng Zheng

11

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8 January 2018

Xiaoxiao Huang

12

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8 January 2018

Mrinal Y Shah

13

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8 January 2018

Sayantan Maji

14

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8 January 2018

Alberto Riva

15

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8 January 2018

Manuela Occhionorelli

16

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8 January 2018

Giovanni Tonon

17

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Neil Kelleher

18

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Jonathan D Licht

20

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8 January 2018

publication date

1 October 2017

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8 January 2018

published in

Cell Reports

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8 January 2018

volume

21

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8 January 2018

page(s)

628-640

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8 January 2018

issue

3

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8 January 2018

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.

cites work

1 reference

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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

23 May 2018

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EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes

23 May 2018

1 reference

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The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

23 May 2018

1 reference

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Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

23 May 2018

1 reference

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Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

23 May 2018

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23 May 2018

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Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

23 May 2018

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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

23 May 2018

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UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells

23 May 2018

1 reference

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Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy

23 May 2018

1 reference

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The mutational landscape of adenoid cystic carcinoma

23 May 2018

1 reference

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EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

23 May 2018

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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

23 May 2018

1 reference

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

23 May 2018

1 reference

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

23 May 2018

1 reference

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UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

23 May 2018

1 reference

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

23 May 2018

1 reference

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MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC.

23 May 2018

1 reference

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Dissecting the genomic complexity underlying medulloblastoma

23 May 2018

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The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis

23 May 2018

1 reference

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Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Suppression of IRF4 by IRF1, 3, and 7 in Noxa expression is a necessary event for IFN-γ-mediated tumor elimination

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression

23 May 2018

1 reference

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Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

The histone demethylase UTX enables RB-dependent cell fate control

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

IRF4 addiction in multiple myeloma

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

Interleukin-6 prevents dexamethasone-induced myeloma cell death.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706555

A687V EZH2 is a gain-of-function mutation found in lymphoma patients

23 May 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29045832

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2017.09.078

1 reference

8 January 2018

release_xb2x2vvujfh6lkjtxqsvfurlsa

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xb2x2vvujfh6lkjtxqsvfurlsa

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

5706555

1 reference

8 January 2018

PubMed ID

29045832

1 reference

8 January 2018