Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival (Q47071359)

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scientific article published on 10 June 2014

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English	Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival	scientific article published on 10 June 2014

Statements

scholarly article

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival (English)

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

phosphorylation

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Akt1 Dmel_CG4006

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GOA release 2020-03-11

author name string

Chia-Lung Chuang

1

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

Yu-Ning Lu

2

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

Hung-Cheng Wang

3

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

Hui-Yun Chang

4

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

publication date

10 June 2014

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

Human Molecular Genetics

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

23

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

5649-5658

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

21

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

Apoptosis in the nervous system

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU281

21 January 2018

Apoptosis in neurodegenerative disorders

1 reference

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Missing pieces in the Parkinson's disease puzzle

1 reference

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Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease

1 reference

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PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage

1 reference

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Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

1 reference

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The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

1 reference

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Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity

1 reference

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PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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LRRK2 signaling pathways: the key to unlocking neurodegeneration?

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Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease

1 reference

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LRRK2 expression in normal and pathologic human brain and in human cell lines

1 reference

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21 January 2018

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

1 reference

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Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

1 reference

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21 January 2018

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU281

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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21 January 2018

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

1 reference

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Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling

1 reference

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21 January 2018

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

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21 January 2018

AKT/PKB signaling: navigating downstream

1 reference

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21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

1 reference

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Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

1 reference

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LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?

1 reference

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Autonomic effects on noise recorded during signal-averaged electrocardiography.

1 reference

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

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21 January 2018

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

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21 January 2018

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

1 reference

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21 January 2018

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

1 reference

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21 January 2018

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

1 reference

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21 January 2018

Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons

1 reference

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21 January 2018

PKB/AKT: functional insights from genetic models

1 reference

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21 January 2018

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU281

21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU281

21 January 2018

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU281

21 January 2018

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU281

21 January 2018

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

1 reference

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21 January 2018

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

1 reference

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21 January 2018

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

1 reference

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21 January 2018

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

1 reference

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21 January 2018

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

1 reference

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21 January 2018

Akt signal transduction dysfunction in Parkinson's disease

1 reference

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21 January 2018

RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation

1 reference

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21 January 2018

Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

1 reference

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21 January 2018

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

1 reference

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Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model

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Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1.

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Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine

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Identifiers

10.1093/HMG/DDU281

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/24916379

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