Ras mediates cell survival by regulating tuberin (Q46961792)

26 December 2017

title

Ras mediates cell survival by regulating tuberin (English)

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26 December 2017

author name string

Freilinger A

1

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26 December 2017

Rosner M

2

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26 December 2017

Hanneder M

3

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26 December 2017

Hengstschläger M

4

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26 December 2017

language of work or name

English

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publication date

8 October 2007

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26 December 2017

published in

Oncogene

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26 December 2017

volume

27

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26 December 2017

page(s)

2072-2083

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26 December 2017

issue

14

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26 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210844

exact match

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cites work

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

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Cell death: critical control points

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PI 3-kinase, Akt and cell survival

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Tuberin activates the proapoptotic molecule BAD.

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

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Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members.

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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TSC2 mediates cellular energy response to control cell growth and survival

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Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes

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Akt regulates growth by directly phosphorylating Tsc2

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Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2

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Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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A role of the tuberous sclerosis gene-2 product during neuronal differentiation

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

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FAS (CD95) mutations are rare in gastric MALT lymphoma but occur more frequently in primary gastric diffuse large B-cell lymphoma

21 January 2018

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

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Mutation of the 9q34 gene TSC1 in sporadic bladder cancer

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inferred from DOI database lookup

7 January 2021

based on heuristic

Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210844

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210844

1 reference

26 December 2017

PubMed ID

17922028

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26 December 2017